IRIS
SIMILE, Maria Maddalena
 Distribuzione geografica
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Continente #
NA - Nord America 4.461
AS - Asia 2.686
EU - Europa 1.729
SA - Sud America 1.581
AF - Africa 81
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 8
Totale 10.558
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Nazione #
US - Stati Uniti d'America 4.333
BR - Brasile 1.444
SG - Singapore 1.161
CN - Cina 869
UA - Ucraina 562
DE - Germania 256
IT - Italia 217
HK - Hong Kong 180
SE - Svezia 157
FR - Francia 114
FI - Finlandia 109
GB - Regno Unito 100
TR - Turchia 95
VN - Vietnam 80
CA - Canada 58
CZ - Repubblica Ceca 45
IN - India 42
AR - Argentina 41
IQ - Iraq 41
RU - Federazione Russa 41
MX - Messico 37
BE - Belgio 33
BD - Bangladesh 29
EC - Ecuador 25
ZA - Sudafrica 25
UZ - Uzbekistan 24
VE - Venezuela 23
ID - Indonesia 22
MA - Marocco 21
PL - Polonia 20
JP - Giappone 19
AT - Austria 17
IR - Iran 16
PK - Pakistan 16
KR - Corea 15
PY - Paraguay 15
LT - Lituania 13
JO - Giordania 12
ES - Italia 11
AU - Australia 10
CO - Colombia 10
CL - Cile 9
KE - Kenya 9
PA - Panama 9
AE - Emirati Arabi Uniti 8
AZ - Azerbaigian 8
EU - Europa 7
NP - Nepal 7
RO - Romania 7
HN - Honduras 6
NL - Olanda 6
SA - Arabia Saudita 6
BG - Bulgaria 5
IL - Israele 5
OM - Oman 5
PE - Perù 5
SN - Senegal 5
TN - Tunisia 5
AM - Armenia 4
BO - Bolivia 4
DO - Repubblica Dominicana 4
EG - Egitto 4
JM - Giamaica 4
KZ - Kazakistan 4
UY - Uruguay 4
DZ - Algeria 3
KG - Kirghizistan 3
SV - El Salvador 3
AL - Albania 2
BH - Bahrain 2
CI - Costa d'Avorio 2
CR - Costa Rica 2
EE - Estonia 2
IE - Irlanda 2
LB - Libano 2
NG - Nigeria 2
NZ - Nuova Zelanda 2
PH - Filippine 2
QA - Qatar 2
RS - Serbia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BN - Brunei Darussalam 1
BS - Bahamas 1
BT - Bhutan 1
BW - Botswana 1
CG - Congo 1
CH - Svizzera 1
DK - Danimarca 1
ET - Etiopia 1
GE - Georgia 1
GT - Guatemala 1
GY - Guiana 1
HT - Haiti 1
LU - Lussemburgo 1
MD - Moldavia 1
ML - Mali 1
MM - Myanmar 1
MN - Mongolia 1
Totale 10.551
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Città #
Dallas 1.462
Chandler 674
Singapore 641
Jacksonville 336
Beijing 188
Hong Kong 179
Princeton 178
Nanjing 137
Ashburn 131
Dearborn 122
Sassari 117
Ann Arbor 99
São Paulo 95
Wilmington 95
Nanchang 69
Rio de Janeiro 68
Boardman 62
Shanghai 62
Izmir 51
Los Angeles 51
Woodbridge 42
Brno 41
Changsha 41
Santa Clara 39
Ho Chi Minh City 37
Shenyang 37
Tianjin 37
Belo Horizonte 33
Brussels 33
Munich 31
New York 30
The Dalles 30
Brasília 28
Hebei 28
Columbus 27
Toronto 27
Jinan 26
Council Bluffs 25
Mountain View 25
Jiaxing 24
Zhengzhou 24
Tashkent 23
Baghdad 22
Porto Alegre 22
Ningbo 20
Helsinki 19
London 19
Tokyo 19
Hangzhou 18
Warsaw 18
Campinas 17
Guarulhos 17
Nuremberg 16
Augusta 15
Goiânia 14
Leawood 14
San Francisco 14
Seoul 14
Boston 13
Chennai 13
San Mateo 13
Amman 12
Ardabil 12
Brooklyn 12
Buffalo 12
Falls Church 12
Hanoi 12
Norwalk 12
Osasco 12
Salvador 12
Stockholm 12
São Bernardo do Campo 12
Andover 11
Denver 11
Frankfurt am Main 11
Johannesburg 11
Praia Grande 11
Taizhou 11
Aracaju 10
Casablanca 10
Curitiba 10
Guangzhou 10
Kunming 10
Lanzhou 10
Aparecida de Goiânia 9
Atlanta 9
Campo Grande 9
Chicago 9
Dhaka 9
Fortaleza 9
Guayaquil 9
Istanbul 9
Maceió 9
Mexico City 9
Nairobi 9
Panama City 9
Quito 9
Santo André 9
Santos 9
Sorocaba 9
Totale 6.224
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Nome #
Alterations of methionine metabolism in hepatocarcinogenesis: the emergent role of glycine N-methyltransferase in liver injury 205
An expression signature of phenotipic resistance to hepatocellular carcinoma identified by cross-species gene expression analysis 200
1-5-formyltetrahydrofolate and 1-5-methyltetrahydrofolate rescue in L-1210 leukemia treated with high methotrexate doses 196
5' Methylthioadenosine administration prevents lipid peroxidation and fibrogenesis induced in rat liver by carbon tetrachloride intoxication 186
Cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis 168
Chemoprevention of rat liver carcinogenesis by S-adenosyl-L-methionine: a long-term study. 166
. Chemoprevention by S-adenosyl-L-methionine of rat liver carcinogenesis initiated by 1,2-dimethylhydrazine and promoted by orotic acid. 162
Correlation of c-myc overexpression and amplification with progression of preneoplastic liver lesions to malignancy in the poorly susceptible Wistar rat strain 160
Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-kappa B and Mat1A genes in the early stages of rat liver carcinogenesis 158
Aberrant iNOS signaling is under genetic control in rodent liver cancer and potentially prognostic for the human disease 157
c-myc amplification in pre-malignant and malignant lesions induced in rat liver by the resistant hepatocyte model 157
INHIBITION OF 3-HYDROXY-3-METHYLGLUTARY-COA REDUCTASE ACTIVITY AND GENE EXPRESSION BY DEHYDROEPIANDROSTERONE IN PRENEOPLASTIC LIVER NODULES 151
Altered methionine metabolism and global DNA methylation in liver cancer: Relationship with genomic instability and prognosis 150
Amplification of c-myc oncogene in preneoplastic e neoplastic lesions induced in rat liver by the resistant hepatocyte protocol 148
The burden of HIV-Associated neurocognitive disorder (HAND) in post-HAART era: Amultidisciplinary review of the literature 146
Chemoprevention of hepatocarcinogenesis: S.adenosyl-L-methionine 145
Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53 141
Targeted therapies in cholangiocarcinoma: emerging evidence from clinical trials 140
Experimental models to define the genetic predisposition to liver cancer 140
Chemopreventive N-(4-hidroxyphenyl)retinamide targets NF-kB and Mat1A genes in early stages of rat liver carcinogenesis. 139
Deregulated c-Myc requires a functional HSF1 for experimental and human hepatocarcinogenesis 139
Role of HSP90,CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer 136
Dependence of benzo(a)pyrene metabolism on NADPH pool in normal and glucose-6-phosphate dehydrogenase deficient human fibroblasts. 135
Down-regulation of c-myc and Cyclin D1 genes by antisense oligodeoxy nucleotides inhibits the expression of E2F1 and in vitro growth of HepG2 and Morris 5123 liver cancer cells 133
MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes 133
Comparative effects of L-methionine, S-adenosyl-L-methionine and 5'-methylthioadenosine on the growth of preneoplastic lesions and DNA methylation in rat liver during the early stages of hepatocarcinogenesis 132
SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis 132
Dual-Specific Phosphatase 1 Ubiquitination in Extracellular Signal-Regulated Kinase-Mediated control of Grawth in Human Hepatocellular Carcinoma 131
Alterations of ornithine decarboxylase gene during the progression of rat liver carcinogenesis. 127
Correlation between S-adenosyl-L-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis. 125
Effect of S-adenosyl-L-methionine on the development of preneoplastic foci and the activity of some carbohydrate metabolizing enzymes in the liver, during experimental hepatocarcinogenesis. 125
Role of transcriptional and postttranscriptional regulation of methionine adenosyltransferases in liver cancer progression. 124
Inhibition by dehydroepiandrosterone of growth and progression of persistent liver nodules in experimental rat liver carcinogenesis 122
Implication of Bcl 2 family genes in basal and D amphetamine induced apoptosis in preneoplastic and neoplastic rat liver lesions 121
ROLE OF YAP SIGNALLING DEREGULATION IN THE GENETIC SUSCEPTIBILITY TO HEPATOCARCINOGENESIS, AND STEMNESS AND AGGRESSIVITY OF LIVER CANCER 120
The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease. 117
THE BN RAT STRAIN CARRIES DOMINANT HEPATOCARCINOGEN RESISTANCE LOCI 116
Inhibition of promotion and persistent nodule growth by S-adenosyl-L-methionine in rat liver carcinogenesis: role of remodeling and apoptosis 115
Identification and chromosome mapping of loci predisposing to colorectal cancer that control Wnt/b-catenin pathway and progression of early lesions in the rat 115
Frequent loss of heterozygosity at the Hcr1 (Hepatocarcinogenesis resistance) locus on chromosome 10 in primary hepatocellular carcinomas from LFF1 rat strain 115
Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma 114
Chromosome mapping of multiple loci affecting the genetic predisposition to rat liver carcinogenesis 114
Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats 114
Modulation by MHC class I antigens of the biology of melanoma cells. Non-immunological mechanisms. 113
Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice 113
Differential effects of dehydroepiandrosterone and deoxyribonucleosides on DNA synthesis and de novo cholesterogenesis in hepatocarcinogenesis in rats. 113
Deregulation of DNA-dependent protein kinase catalytic subunit contributes to human hepatocarcinogenesis development and has a putative prognostic value 112
Protooncogene methylation and expression in regenerating liver and preneoplastic liver nodules induced in the rat by diethylnitrosamine: effect of variations of S-adenosylmethionine:S-adenosylhomocysteine ratio. 112
Alterations of methionine metabolism as potential targets for the prevention and therapy of hepatocellular carcinoma 112
Induction by human interferon and murine h-2l(d) gene of the surface expression of endogenous hla class-I free heavy-chains in hct human colon-carcinoma cells, deficient in Beta-2-microglobulin 111
Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans 111
Transferrin and transferrin receptor gene expression and iron upteke in hepatocellular carcinoma in the rat 109
Identification of genetic loci controlling hepatocarcinogenesis on rat chromosomes 7 and 10 109
Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC 106
Long-term dehydroepiandrosterone and 16alfa-fluoro-5-androsten-17-one administration enhances DNA synthesis and induces expression of c-fos and c-Ha-ras in a selected population of preneoplastic lesions in liver of diethylnitrosamine-initiated rats 106
Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype 105
Persistent chemopreventive effect of S-adenosyl-L-methionine on the development of liver putative preneoplastic lesions induced by thiobenzamide in diethylnitrosamine-initiated rats 104
Simile, M.M., Pagnan, G., De Miglio, M.R., Muroni, M.R., Asara, G., Frau, M., Seddaiu M.A., Feo, F., Ponzoni, M., and Pascale, R.M 104
Phenotypic reversion of rat neoplastic liver nodules is under genetic control 103
Polygenic control of hepatocarcinogenesis in Copenhagen x F344 rats 103
Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease 103
The post-transcriptional dysregulation of methionine adenosyl-transferases is crucial for the progression of rat and human liver cancer. 47° Annual Meeting of the European Association for Study of the Liver (EASL) Aprile 18-22, 2012 100
Reversal by ribo- and deoxyribonucleosides of dehydroepiandrosterone-induced inhibition of enzyme altered foci in the liver of rats subjected to the initiation--selection process of experimental carcinogenesis. 97
Ruolo di HSP90, CDC37 e CRM1 come modulatori dell’attività di p16 INK4A nella cancerogenesi epatica di ratto e nel carcinoma epatocellulare umano 93
The warburg effect 97 years after its discovery 92
New putative prognostic markers and therapeutic targets for the molecular approach to treatment of hepatocellular carcinoma 92
Epigenetics of liver cancer progression: Role of transcriptional and post-transcriptional regulation of methionine adenosyltransferases in liver cancer progression. 91
Polygenic control of hepatocarcinogenesis in Copenhagen x F344 rats 89
Inhibition of 3-hydroxy-3- methylglutaryl-CoA reductase activity and gene expression by dehydroepiandrosterone in preneolastic liver nodules 83
Ras-driven proliferation and apoptosis signaling during rat liver carcinogenesis is under genetic control 82
Focal loss of long non-coding RNA-PRAL, as determinant of cell function and phenotype of hepatocellular carcinoma 82
Nuclear localization dictates hepatocarcinogenesis suppression by glycine N-methyltransferase 81
Mapping a sex-hormone sensitive gene determining female resistance to liver carcinogenesis in a congenic F344 BN-Hcs4 rat. 81
Transferrin and transferrin receptor gene expression in benign and malignant rat liver lesions. 80
Reversal by 5-azacytidine of the s-adenosyl-L-methionine induced inhibition of the development of putative preneoplastic foci in rat-liver 80
Polygenic predisposition to hepatocellular carcinoma. 80
Genetic alterations in liver carcinogenesis: implication for new preventive therapeutic strategies 79
Reversal by 5-azacytidine of the S-adenosyl-L-methionine-induced inhibition of the development of putative preneoplastic foci in rat liver carcinogenesis 79
Modulation of P16INK4A activity by Hsp90, Cdc37 and CRM1 influences the progression of preneoplastic lesions in rats with different predisposition to liver cancer and the prognosis of human hepatocellular carcinoma 79
Re-expression of the major histocompatibility complex (MHC) class I antigen H-2K b by M1 (B16-F10) murine melanoma cells 78
Genomic abnormalities in hepatocarcinogenesis. Implications for a chemopreventive strategy. 76
S-Adenosylmethionine: From the Discovery of Its Inhibition of Tumorigenesis to Its Use as a Therapeutic Agent 75
Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC 74
Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC. 45° Annual Meeting of the European Association for the Study of the Liver (EASL) Aprile 14-18, 2010 74
Hepatocellular carcinoma as a complex polygenic disease. Interpretative analysis of recent developments on genetic predisposition 72
Mapping a sex hormone-sensitive gene determining female resistance to liver carcinogenesis in a congenic F344.BN-Hcs4 rat 67
Identification and characterization of a cDNA clone for a gene overexpressed in preneoplastic e neoplastic lesions in rat liver 67
Role of perturbation of methionine metabolism and global DNA methylation in the generation of genomic instability in transgenic mouse models of liver cancer 67
HSF1 is a prognostic determinant and therapeutic target in intrahepatic cholangiocarcinoma 66
Fatty Acid Synthase Promotes Hepatocellular Carcinoma Growth via S-Phase Kinase-Associated Protein 2/p27KIP1 Regulation 63
Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis 62
Sequential analysis of epigenetic and genetic events during rat liver carcinogenesis. 62
eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma 59
Post-translational inhibition of YAP oncogene expression by 4-hydroxynonenal in bladder cancer cells 56
Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma 53
Genetic Predisposition to Hepatocellular Carcinoma 43
Totale 10.673
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Categoria #
all - tutte 42.783
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 42.783
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021488 0 0 0 0 0 31 93 5 117 118 102 22
2021/2022511 77 5 5 7 12 22 29 25 46 29 53 201
2022/20231.160 126 109 25 213 99 194 0 128 185 7 46 28
2023/2024290 58 20 6 10 38 4 0 23 0 3 39 89
2024/20253.076 21 26 158 95 152 99 246 534 1.004 492 163 86
2025/20263.065 217 1.134 684 523 401 106 0 0 0 0 0 0
Totale 10.673