IRIS
SIMILE, Maria Maddalena
 Distribuzione geografica
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Continente #
NA - Nord America 2.360
EU - Europa 1.475
AS - Asia 959
OC - Oceania 10
Continente sconosciuto - Info sul continente non disponibili 8
SA - Sud America 2
Totale 4.814
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Nazione #
US - Stati Uniti d'America 2.328
CN - Cina 592
UA - Ucraina 550
SG - Singapore 249
DE - Germania 211
IT - Italia 201
SE - Svezia 147
FR - Francia 111
FI - Finlandia 89
GB - Regno Unito 63
TR - Turchia 54
CZ - Repubblica Ceca 44
BE - Belgio 30
CA - Canada 30
ID - Indonesia 16
IR - Iran 14
IN - India 13
KR - Corea 12
AU - Australia 9
EU - Europa 7
RO - Romania 7
AT - Austria 5
LT - Lituania 4
BD - Bangladesh 3
BR - Brasile 2
EE - Estonia 2
IE - Irlanda 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AE - Emirati Arabi Uniti 1
BG - Bulgaria 1
BT - Bhutan 1
CH - Svizzera 1
ES - Italia 1
IL - Israele 1
LU - Lussemburgo 1
MM - Myanmar 1
MT - Malta 1
MX - Messico 1
NL - Olanda 1
NP - Nepal 1
NZ - Nuova Zelanda 1
PA - Panama 1
PL - Polonia 1
RU - Federazione Russa 1
SA - Arabia Saudita 1
SI - Slovenia 1
Totale 4.814
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Città #
Chandler 674
Jacksonville 336
Singapore 193
Princeton 178
Nanjing 137
Dearborn 122
Sassari 116
Ann Arbor 99
Wilmington 95
Nanchang 69
Beijing 60
Boardman 59
Izmir 49
Woodbridge 42
Brno 41
Changsha 40
Shenyang 37
Tianjin 32
Brussels 30
Hebei 28
Ashburn 26
Jinan 25
Mountain View 25
Jiaxing 24
Zhengzhou 24
Santa Clara 23
Toronto 21
Ningbo 20
Hangzhou 17
Munich 16
Augusta 14
Leawood 14
San Mateo 13
Ardabil 12
Dallas 12
Falls Church 12
Norwalk 12
Andover 11
Seoul 11
Taizhou 11
Guangzhou 10
Helsinki 10
Lanzhou 10
Kunming 9
Monmouth Junction 8
London 7
Los Angeles 7
New York 7
Ottawa 7
San Francisco 7
Cagliari 6
Tappahannock 6
Auburn Hills 5
Changchun 5
Frankfurt am Main 4
Hefei 4
Romola 4
Vienna 4
Berlin 3
Canberra 3
Chicago 3
Grézieu-la-varenne 3
Haikou 3
Melbourne 3
Messina 3
Mumbai 3
Olomouc 3
Perugia 3
Rome 3
Shanghai 3
Alghero 2
Beinasco 2
Cedar Knolls 2
Città Di Castello 2
Cortoghiana 2
Dublin 2
Edinburgh 2
Milan 2
Stockholm 2
Tallinn 2
Torino 2
Betim 1
Braila 1
Bridlington 1
Brierley Hill 1
Chalfont 1
Chengdu 1
Chittagong 1
Dhaka 1
Dubai 1
Edmonton 1
Espoo 1
Falkenstein 1
Fremont 1
Fuzhou 1
Haifa 1
Huntington 1
Il-Madliena 1
Kathmandu 1
Krakow 1
Totale 2.977
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Nome #
INHIBITION OF 3-HYDROXY-3-METHYLGLUTARY-COA REDUCTASE ACTIVITY AND GENE EXPRESSION BY DEHYDROEPIANDROSTERONE IN PRENEOPLASTIC LIVER NODULES 94
1-5-formyltetrahydrofolate and 1-5-methyltetrahydrofolate rescue in L-1210 leukemia treated with high methotrexate doses 91
The burden of HIV-Associated neurocognitive disorder (HAND) in post-HAART era: Amultidisciplinary review of the literature 90
Correlation of c-myc overexpression and amplification with progression of preneoplastic liver lesions to malignancy in the poorly susceptible Wistar rat strain 87
Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-kappa B and Mat1A genes in the early stages of rat liver carcinogenesis 84
Role of HSP90,CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer 80
Targeted therapies in cholangiocarcinoma: emerging evidence from clinical trials 77
Alterations of methionine metabolism in hepatocarcinogenesis: the emergent role of glycine N-methyltransferase in liver injury 77
Down-regulation of c-myc and Cyclin D1 genes by antisense oligodeoxy nucleotides inhibits the expression of E2F1 and in vitro growth of HepG2 and Morris 5123 liver cancer cells 75
Modulation by MHC class I antigens of the biology of melanoma cells. Non-immunological mechanisms. 73
Deregulated c-Myc requires a functional HSF1 for experimental and human hepatocarcinogenesis 70
Chemoprevention of hepatocarcinogenesis: S.adenosyl-L-methionine 68
Induction by human interferon and murine h-2l(d) gene of the surface expression of endogenous hla class-I free heavy-chains in hct human colon-carcinoma cells, deficient in Beta-2-microglobulin 67
Frequent loss of heterozygosity at the Hcr1 (Hepatocarcinogenesis resistance) locus on chromosome 10 in primary hepatocellular carcinomas from LFF1 rat strain 67
Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease 66
ROLE OF YAP SIGNALLING DEREGULATION IN THE GENETIC SUSCEPTIBILITY TO HEPATOCARCINOGENESIS, AND STEMNESS AND AGGRESSIVITY OF LIVER CANCER 66
Experimental models to define the genetic predisposition to liver cancer 66
Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans 64
Dependence of benzo(a)pyrene metabolism on NADPH pool in normal and glucose-6-phosphate dehydrogenase deficient human fibroblasts. 63
MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes 63
Inhibition of promotion and persistent nodule growth by S-adenosyl-L-methionine in rat liver carcinogenesis: role of remodeling and apoptosis 61
5' Methylthioadenosine administration prevents lipid peroxidation and fibrogenesis induced in rat liver by carbon tetrachloride intoxication 61
Implication of Bcl 2 family genes in basal and D amphetamine induced apoptosis in preneoplastic and neoplastic rat liver lesions 61
Effect of S-adenosyl-L-methionine on the development of preneoplastic foci and the activity of some carbohydrate metabolizing enzymes in the liver, during experimental hepatocarcinogenesis. 60
Chemoprevention of rat liver carcinogenesis by S-adenosyl-L-methionine: a long-term study. 59
Phenotypic reversion of rat neoplastic liver nodules is under genetic control 58
Identification and chromosome mapping of loci predisposing to colorectal cancer that control Wnt/b-catenin pathway and progression of early lesions in the rat 58
Reversal by ribo- and deoxyribonucleosides of dehydroepiandrosterone-induced inhibition of enzyme altered foci in the liver of rats subjected to the initiation--selection process of experimental carcinogenesis. 58
c-myc amplification in pre-malignant and malignant lesions induced in rat liver by the resistant hepatocyte model 58
Dual-Specific Phosphatase 1 Ubiquitination in Extracellular Signal-Regulated Kinase-Mediated control of Grawth in Human Hepatocellular Carcinoma 58
Altered methionine metabolism and global DNA methylation in liver cancer: Relationship with genomic instability and prognosis 58
Identification of genetic loci controlling hepatocarcinogenesis on rat chromosomes 7 and 10 57
THE BN RAT STRAIN CARRIES DOMINANT HEPATOCARCINOGEN RESISTANCE LOCI 57
Chromosome mapping of multiple loci affecting the genetic predisposition to rat liver carcinogenesis 57
Polygenic control of hepatocarcinogenesis in Copenhagen x F344 rats 56
Amplification of c-myc oncogene in preneoplastic e neoplastic lesions induced in rat liver by the resistant hepatocyte protocol 56
Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma 56
SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis 56
Cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis 56
Protooncogene methylation and expression in regenerating liver and preneoplastic liver nodules induced in the rat by diethylnitrosamine: effect of variations of S-adenosylmethionine:S-adenosylhomocysteine ratio. 55
Inhibition by dehydroepiandrosterone of growth and progression of persistent liver nodules in experimental rat liver carcinogenesis 55
Persistent chemopreventive effect of S-adenosyl-L-methionine on the development of liver putative preneoplastic lesions induced by thiobenzamide in diethylnitrosamine-initiated rats 55
. Chemoprevention by S-adenosyl-L-methionine of rat liver carcinogenesis initiated by 1,2-dimethylhydrazine and promoted by orotic acid. 55
Long-term dehydroepiandrosterone and 16alfa-fluoro-5-androsten-17-one administration enhances DNA synthesis and induces expression of c-fos and c-Ha-ras in a selected population of preneoplastic lesions in liver of diethylnitrosamine-initiated rats 55
Comparative effects of L-methionine, S-adenosyl-L-methionine and 5'-methylthioadenosine on the growth of preneoplastic lesions and DNA methylation in rat liver during the early stages of hepatocarcinogenesis 54
Aberrant iNOS signaling is under genetic control in rodent liver cancer and potentially prognostic for the human disease 54
Differential effects of dehydroepiandrosterone and deoxyribonucleosides on DNA synthesis and de novo cholesterogenesis in hepatocarcinogenesis in rats. 54
Alterations of ornithine decarboxylase gene during the progression of rat liver carcinogenesis. 54
An expression signature of phenotipic resistance to hepatocellular carcinoma identified by cross-species gene expression analysis 54
Transferrin and transferrin receptor gene expression and iron upteke in hepatocellular carcinoma in the rat 52
Chemopreventive N-(4-hidroxyphenyl)retinamide targets NF-kB and Mat1A genes in early stages of rat liver carcinogenesis. 52
Role of transcriptional and postttranscriptional regulation of methionine adenosyltransferases in liver cancer progression. 52
Simile, M.M., Pagnan, G., De Miglio, M.R., Muroni, M.R., Asara, G., Frau, M., Seddaiu M.A., Feo, F., Ponzoni, M., and Pascale, R.M 52
New putative prognostic markers and therapeutic targets for the molecular approach to treatment of hepatocellular carcinoma 52
Deregulation of DNA-dependent protein kinase catalytic subunit contributes to human hepatocarcinogenesis development and has a putative prognostic value 51
Mapping a sex-hormone sensitive gene determining female resistance to liver carcinogenesis in a congenic F344 BN-Hcs4 rat. 51
Ruolo di HSP90, CDC37 e CRM1 come modulatori dell’attività di p16 INK4A nella cancerogenesi epatica di ratto e nel carcinoma epatocellulare umano 50
Epigenetics of liver cancer progression: Role of transcriptional and post-transcriptional regulation of methionine adenosyltransferases in liver cancer progression. 50
Correlation between S-adenosyl-L-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis. 50
Genetic alterations in liver carcinogenesis: implication for new preventive therapeutic strategies 49
Transferrin and transferrin receptor gene expression in benign and malignant rat liver lesions. 49
Ras-driven proliferation and apoptosis signaling during rat liver carcinogenesis is under genetic control 48
The post-transcriptional dysregulation of methionine adenosyl-transferases is crucial for the progression of rat and human liver cancer. 47° Annual Meeting of the European Association for Study of the Liver (EASL) Aprile 18-22, 2012 48
Reversal by 5-azacytidine of the S-adenosyl-L-methionine-induced inhibition of the development of putative preneoplastic foci in rat liver carcinogenesis 48
Polygenic control of hepatocarcinogenesis in Copenhagen x F344 rats 48
Focal loss of long non-coding RNA-PRAL, as determinant of cell function and phenotype of hepatocellular carcinoma 47
Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats 47
Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype 47
Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice 46
Identification and characterization of a cDNA clone for a gene overexpressed in preneoplastic e neoplastic lesions in rat liver 44
Mapping a sex hormone-sensitive gene determining female resistance to liver carcinogenesis in a congenic F344.BN-Hcs4 rat 43
Polygenic predisposition to hepatocellular carcinoma. 43
Role of perturbation of methionine metabolism and global DNA methylation in the generation of genomic instability in transgenic mouse models of liver cancer 43
Hepatocellular carcinoma as a complex polygenic disease. Interpretative analysis of recent developments on genetic predisposition 43
The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease. 42
Sequential analysis of epigenetic and genetic events during rat liver carcinogenesis. 41
Modulation of P16INK4A activity by Hsp90, Cdc37 and CRM1 influences the progression of preneoplastic lesions in rats with different predisposition to liver cancer and the prognosis of human hepatocellular carcinoma 41
Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC. 45° Annual Meeting of the European Association for the Study of the Liver (EASL) Aprile 14-18, 2010 39
Re-expression of the major histocompatibility complex (MHC) class I antigen H-2K b by M1 (B16-F10) murine melanoma cells 39
Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53 39
Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC 38
Genomic abnormalities in hepatocarcinogenesis. Implications for a chemopreventive strategy. 36
Reversal by 5-azacytidine of the s-adenosyl-L-methionine induced inhibition of the development of putative preneoplastic foci in rat-liver 36
Post-translational inhibition of YAP oncogene expression by 4-hydroxynonenal in bladder cancer cells 33
Inhibition of 3-hydroxy-3- methylglutaryl-CoA reductase activity and gene expression by dehydroepiandrosterone in preneolastic liver nodules 31
The warburg effect 97 years after its discovery 31
Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC 30
Nuclear localization dictates hepatocarcinogenesis suppression by glycine N-methyltransferase 29
Alterations of methionine metabolism as potential targets for the prevention and therapy of hepatocellular carcinoma 23
HSF1 is a prognostic determinant and therapeutic target in intrahepatic cholangiocarcinoma 12
eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma 12
Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma 8
Genetic Predisposition to Hepatocellular Carcinoma 8
Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis 6
Fatty Acid Synthase Promotes Hepatocellular Carcinoma Growth via S-Phase Kinase-Associated Protein 2/p27KIP1 Regulation 4
S-Adenosylmethionine: From the Discovery of Its Inhibition of Tumorigenesis to Its Use as a Therapeutic Agent 4
Totale 4.921
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Categoria #
all - tutte 25.724
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 25.724
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020704 0 0 0 0 84 101 231 25 104 51 99 9
2020/2021790 93 0 114 10 85 31 93 5 117 118 102 22
2021/2022511 77 5 5 7 12 22 29 25 46 29 53 201
2022/20231.160 126 109 25 213 99 194 0 128 185 7 46 28
2023/2024290 58 20 6 10 38 4 0 23 0 3 39 89
2024/2025389 21 26 158 95 89 0 0 0 0 0 0 0
Totale 4.921