IRIS
SIMILE, Maria Maddalena
 Distribuzione geografica
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Continente #
NA - Nord America 4.988
AS - Asia 3.202
EU - Europa 1.883
SA - Sud America 1.625
AF - Africa 102
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 8
Totale 11.820
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Nazione #
US - Stati Uniti d'America 4.849
BR - Brasile 1.470
SG - Singapore 1.297
CN - Cina 1.008
UA - Ucraina 564
DE - Germania 262
IT - Italia 224
VN - Vietnam 210
HK - Hong Kong 207
FR - Francia 204
SE - Svezia 159
GB - Regno Unito 133
FI - Finlandia 110
TR - Turchia 96
IN - India 63
CA - Canada 62
IQ - Iraq 53
AR - Argentina 46
CZ - Repubblica Ceca 45
RU - Federazione Russa 42
MX - Messico 39
BD - Bangladesh 35
BE - Belgio 33
ZA - Sudafrica 29
UZ - Uzbekistan 27
EC - Ecuador 26
VE - Venezuela 26
ID - Indonesia 25
MA - Marocco 25
PK - Pakistan 25
JP - Giappone 20
PL - Polonia 20
AT - Austria 19
IR - Iran 16
JO - Giordania 16
CO - Colombia 15
KR - Corea 15
PY - Paraguay 15
ES - Italia 14
LT - Lituania 13
SA - Arabia Saudita 12
KE - Kenya 11
AU - Australia 10
PA - Panama 10
CL - Cile 9
AE - Emirati Arabi Uniti 8
AZ - Azerbaigian 8
NL - Olanda 8
NP - Nepal 8
EU - Europa 7
RO - Romania 7
TN - Tunisia 7
HN - Honduras 6
IL - Israele 6
OM - Oman 6
PE - Perù 6
SN - Senegal 6
UY - Uruguay 6
BG - Bulgaria 5
BO - Bolivia 5
EG - Egitto 5
JM - Giamaica 5
KZ - Kazakistan 5
MY - Malesia 5
PH - Filippine 5
AM - Armenia 4
CI - Costa d'Avorio 4
DO - Repubblica Dominicana 4
NG - Nigeria 4
SY - Repubblica araba siriana 4
CR - Costa Rica 3
DZ - Algeria 3
KG - Kirghizistan 3
LB - Libano 3
QA - Qatar 3
SV - El Salvador 3
AL - Albania 2
BH - Bahrain 2
CG - Congo 2
EE - Estonia 2
ET - Etiopia 2
GE - Georgia 2
IE - Irlanda 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
RS - Serbia 2
SI - Slovenia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BN - Brunei Darussalam 1
BS - Bahamas 1
BT - Bhutan 1
BW - Botswana 1
BY - Bielorussia 1
CH - Svizzera 1
DK - Danimarca 1
GD - Grenada 1
GT - Guatemala 1
GY - Guiana 1
Totale 11.806
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Città #
Dallas 1.462
Singapore 721
Chandler 674
Jacksonville 336
San Jose 329
Ashburn 228
Beijing 208
Hong Kong 205
Princeton 178
Nanjing 137
Dearborn 122
Sassari 117
Ann Arbor 99
São Paulo 98
Wilmington 95
Lauterbourg 88
Ho Chi Minh City 75
Nanchang 69
Rio de Janeiro 69
Shanghai 65
Boardman 62
Los Angeles 61
Santa Clara 54
Izmir 51
Hanoi 50
Changsha 42
Woodbridge 42
Brno 41
Shenyang 38
Tianjin 37
Council Bluffs 35
Belo Horizonte 33
Brussels 33
New York 33
Munich 31
The Dalles 30
Brasília 28
Hebei 28
Toronto 28
Columbus 27
Jinan 26
Baghdad 25
Mountain View 25
Tashkent 25
Jiaxing 24
London 24
Orem 24
Zhengzhou 24
Porto Alegre 22
Chennai 20
Ningbo 20
Tokyo 20
Helsinki 19
Nuremberg 19
Campinas 18
Hangzhou 18
Warsaw 18
Guarulhos 17
Amman 16
Goiânia 16
Augusta 15
Johannesburg 15
Boston 14
Frankfurt am Main 14
Leawood 14
San Francisco 14
Seoul 14
Stockholm 14
Denver 13
San Mateo 13
Ardabil 12
Brooklyn 12
Buffalo 12
Casablanca 12
Falls Church 12
Norwalk 12
Osasco 12
Salvador 12
São Bernardo do Campo 12
Andover 11
Chicago 11
Guangzhou 11
Nairobi 11
Praia Grande 11
Taizhou 11
Aracaju 10
Curitiba 10
Dhaka 10
Istanbul 10
Kunming 10
Lanzhou 10
Montreal 10
Panama City 10
Santo André 10
Aparecida de Goiânia 9
Atlanta 9
Biên Hòa 9
Campo Grande 9
Da Nang 9
Fortaleza 9
Totale 7.037
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Nome #
Alterations of methionine metabolism in hepatocarcinogenesis: the emergent role of glycine N-methyltransferase in liver injury 230
An expression signature of phenotipic resistance to hepatocellular carcinoma identified by cross-species gene expression analysis 215
1-5-formyltetrahydrofolate and 1-5-methyltetrahydrofolate rescue in L-1210 leukemia treated with high methotrexate doses 214
5' Methylthioadenosine administration prevents lipid peroxidation and fibrogenesis induced in rat liver by carbon tetrachloride intoxication 202
Chemoprevention of rat liver carcinogenesis by S-adenosyl-L-methionine: a long-term study. 186
Cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis 184
. Chemoprevention by S-adenosyl-L-methionine of rat liver carcinogenesis initiated by 1,2-dimethylhydrazine and promoted by orotic acid. 182
Aberrant iNOS signaling is under genetic control in rodent liver cancer and potentially prognostic for the human disease 179
Correlation of c-myc overexpression and amplification with progression of preneoplastic liver lesions to malignancy in the poorly susceptible Wistar rat strain 179
c-myc amplification in pre-malignant and malignant lesions induced in rat liver by the resistant hepatocyte model 175
Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-kappa B and Mat1A genes in the early stages of rat liver carcinogenesis 174
Altered methionine metabolism and global DNA methylation in liver cancer: Relationship with genomic instability and prognosis 172
Chemoprevention of hepatocarcinogenesis: S.adenosyl-L-methionine 170
INHIBITION OF 3-HYDROXY-3-METHYLGLUTARY-COA REDUCTASE ACTIVITY AND GENE EXPRESSION BY DEHYDROEPIANDROSTERONE IN PRENEOPLASTIC LIVER NODULES 168
Amplification of c-myc oncogene in preneoplastic e neoplastic lesions induced in rat liver by the resistant hepatocyte protocol 160
The burden of HIV-Associated neurocognitive disorder (HAND) in post-HAART era: Amultidisciplinary review of the literature 159
Targeted therapies in cholangiocarcinoma: emerging evidence from clinical trials 157
Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53 157
Experimental models to define the genetic predisposition to liver cancer 157
Deregulated c-Myc requires a functional HSF1 for experimental and human hepatocarcinogenesis 156
Dependence of benzo(a)pyrene metabolism on NADPH pool in normal and glucose-6-phosphate dehydrogenase deficient human fibroblasts. 155
Comparative effects of L-methionine, S-adenosyl-L-methionine and 5'-methylthioadenosine on the growth of preneoplastic lesions and DNA methylation in rat liver during the early stages of hepatocarcinogenesis 152
Chemopreventive N-(4-hidroxyphenyl)retinamide targets NF-kB and Mat1A genes in early stages of rat liver carcinogenesis. 151
Role of HSP90,CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer 150
MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes 150
Down-regulation of c-myc and Cyclin D1 genes by antisense oligodeoxy nucleotides inhibits the expression of E2F1 and in vitro growth of HepG2 and Morris 5123 liver cancer cells 147
Dual-Specific Phosphatase 1 Ubiquitination in Extracellular Signal-Regulated Kinase-Mediated control of Grawth in Human Hepatocellular Carcinoma 145
Alterations of ornithine decarboxylase gene during the progression of rat liver carcinogenesis. 145
Inhibition of promotion and persistent nodule growth by S-adenosyl-L-methionine in rat liver carcinogenesis: role of remodeling and apoptosis 143
Effect of S-adenosyl-L-methionine on the development of preneoplastic foci and the activity of some carbohydrate metabolizing enzymes in the liver, during experimental hepatocarcinogenesis. 143
SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis 141
Correlation between S-adenosyl-L-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis. 138
Implication of Bcl 2 family genes in basal and D amphetamine induced apoptosis in preneoplastic and neoplastic rat liver lesions 138
Inhibition by dehydroepiandrosterone of growth and progression of persistent liver nodules in experimental rat liver carcinogenesis 137
Identification and chromosome mapping of loci predisposing to colorectal cancer that control Wnt/b-catenin pathway and progression of early lesions in the rat 136
Role of transcriptional and postttranscriptional regulation of methionine adenosyltransferases in liver cancer progression. 136
Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans 136
Chromosome mapping of multiple loci affecting the genetic predisposition to rat liver carcinogenesis 134
Alterations of methionine metabolism as potential targets for the prevention and therapy of hepatocellular carcinoma 131
ROLE OF YAP SIGNALLING DEREGULATION IN THE GENETIC SUSCEPTIBILITY TO HEPATOCARCINOGENESIS, AND STEMNESS AND AGGRESSIVITY OF LIVER CANCER 129
Deregulation of DNA-dependent protein kinase catalytic subunit contributes to human hepatocarcinogenesis development and has a putative prognostic value 128
The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease. 127
Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma 126
Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice 126
Frequent loss of heterozygosity at the Hcr1 (Hepatocarcinogenesis resistance) locus on chromosome 10 in primary hepatocellular carcinomas from LFF1 rat strain 126
Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats 126
Differential effects of dehydroepiandrosterone and deoxyribonucleosides on DNA synthesis and de novo cholesterogenesis in hepatocarcinogenesis in rats. 125
Protooncogene methylation and expression in regenerating liver and preneoplastic liver nodules induced in the rat by diethylnitrosamine: effect of variations of S-adenosylmethionine:S-adenosylhomocysteine ratio. 124
THE BN RAT STRAIN CARRIES DOMINANT HEPATOCARCINOGEN RESISTANCE LOCI 124
Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC 122
Long-term dehydroepiandrosterone and 16alfa-fluoro-5-androsten-17-one administration enhances DNA synthesis and induces expression of c-fos and c-Ha-ras in a selected population of preneoplastic lesions in liver of diethylnitrosamine-initiated rats 120
Transferrin and transferrin receptor gene expression and iron upteke in hepatocellular carcinoma in the rat 119
Identification of genetic loci controlling hepatocarcinogenesis on rat chromosomes 7 and 10 119
Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease 119
Induction by human interferon and murine h-2l(d) gene of the surface expression of endogenous hla class-I free heavy-chains in hct human colon-carcinoma cells, deficient in Beta-2-microglobulin 118
Persistent chemopreventive effect of S-adenosyl-L-methionine on the development of liver putative preneoplastic lesions induced by thiobenzamide in diethylnitrosamine-initiated rats 117
Simile, M.M., Pagnan, G., De Miglio, M.R., Muroni, M.R., Asara, G., Frau, M., Seddaiu M.A., Feo, F., Ponzoni, M., and Pascale, R.M 117
Modulation by MHC class I antigens of the biology of melanoma cells. Non-immunological mechanisms. 116
Phenotypic reversion of rat neoplastic liver nodules is under genetic control 115
Polygenic control of hepatocarcinogenesis in Copenhagen x F344 rats 112
Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype 107
Epigenetics of liver cancer progression: Role of transcriptional and post-transcriptional regulation of methionine adenosyltransferases in liver cancer progression. 106
The warburg effect 97 years after its discovery 106
The post-transcriptional dysregulation of methionine adenosyl-transferases is crucial for the progression of rat and human liver cancer. 47° Annual Meeting of the European Association for Study of the Liver (EASL) Aprile 18-22, 2012 105
Inhibition of 3-hydroxy-3- methylglutaryl-CoA reductase activity and gene expression by dehydroepiandrosterone in preneolastic liver nodules 103
Reversal by ribo- and deoxyribonucleosides of dehydroepiandrosterone-induced inhibition of enzyme altered foci in the liver of rats subjected to the initiation--selection process of experimental carcinogenesis. 103
New putative prognostic markers and therapeutic targets for the molecular approach to treatment of hepatocellular carcinoma 103
Ruolo di HSP90, CDC37 e CRM1 come modulatori dell’attività di p16 INK4A nella cancerogenesi epatica di ratto e nel carcinoma epatocellulare umano 98
Reversal by 5-azacytidine of the S-adenosyl-L-methionine-induced inhibition of the development of putative preneoplastic foci in rat liver carcinogenesis 98
Focal loss of long non-coding RNA-PRAL, as determinant of cell function and phenotype of hepatocellular carcinoma 97
Polygenic control of hepatocarcinogenesis in Copenhagen x F344 rats 97
Ras-driven proliferation and apoptosis signaling during rat liver carcinogenesis is under genetic control 94
Mapping a sex-hormone sensitive gene determining female resistance to liver carcinogenesis in a congenic F344 BN-Hcs4 rat. 92
Modulation of P16INK4A activity by Hsp90, Cdc37 and CRM1 influences the progression of preneoplastic lesions in rats with different predisposition to liver cancer and the prognosis of human hepatocellular carcinoma 90
Transferrin and transferrin receptor gene expression in benign and malignant rat liver lesions. 88
Nuclear localization dictates hepatocarcinogenesis suppression by glycine N-methyltransferase 88
Polygenic predisposition to hepatocellular carcinoma. 88
Re-expression of the major histocompatibility complex (MHC) class I antigen H-2K b by M1 (B16-F10) murine melanoma cells 88
S-Adenosylmethionine: From the Discovery of Its Inhibition of Tumorigenesis to Its Use as a Therapeutic Agent 88
Genetic alterations in liver carcinogenesis: implication for new preventive therapeutic strategies 87
Reversal by 5-azacytidine of the s-adenosyl-L-methionine induced inhibition of the development of putative preneoplastic foci in rat-liver 87
Genomic abnormalities in hepatocarcinogenesis. Implications for a chemopreventive strategy. 86
Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC 82
Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC. 45° Annual Meeting of the European Association for the Study of the Liver (EASL) Aprile 14-18, 2010 82
Hepatocellular carcinoma as a complex polygenic disease. Interpretative analysis of recent developments on genetic predisposition 77
Fatty Acid Synthase Promotes Hepatocellular Carcinoma Growth via S-Phase Kinase-Associated Protein 2/p27KIP1 Regulation 75
Mapping a sex hormone-sensitive gene determining female resistance to liver carcinogenesis in a congenic F344.BN-Hcs4 rat 75
HSF1 is a prognostic determinant and therapeutic target in intrahepatic cholangiocarcinoma 74
Identification and characterization of a cDNA clone for a gene overexpressed in preneoplastic e neoplastic lesions in rat liver 74
Sequential analysis of epigenetic and genetic events during rat liver carcinogenesis. 72
Role of perturbation of methionine metabolism and global DNA methylation in the generation of genomic instability in transgenic mouse models of liver cancer 72
Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis 71
Post-translational inhibition of YAP oncogene expression by 4-hydroxynonenal in bladder cancer cells 67
eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma 65
Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma 61
Genetic Predisposition to Hepatocellular Carcinoma 50
Totale 11.935
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Categoria #
all - tutte 45.373
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 45.373
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021242 0 0 0 0 0 0 0 0 0 118 102 22
2021/2022511 77 5 5 7 12 22 29 25 46 29 53 201
2022/20231.160 126 109 25 213 99 194 0 128 185 7 46 28
2023/2024290 58 20 6 10 38 4 0 23 0 3 39 89
2024/20253.076 21 26 158 95 152 99 246 534 1.004 492 163 86
2025/20264.327 217 1.134 684 523 401 267 604 127 179 191 0 0
Totale 11.935