Quantitative evaluation of single-shot inline phase contrast imaging using an inverse compton x-ray source

Inverse compton scattering (ICS) x-ray sources are of current interest in biomedical imaging. We present an experimental demonstration of inline phase contrast imaging using a single picosecond pulse of the ICS source located at the BNL Accelerator Test Facility. The phase contrast effect is clearly observed. Its qualities are shown to be in agreement with the predictions of theoretical models through comparison of experimental and simulated images of a set of plastic wires of differing composition and size. Finally, we display an application of the technique to a biological sample, confirming the possibility of time-resolved imaging on the picosecond scale.

Inverse compton scattering (ICS) x-ray sources are of current interest in biomedical imaging. We present an experimental demonstration of inline phase contrast imaging using a single picosecond pulse of the ICS source located at the BNL Accelerator Test Facility. The phase contrast effect is clearly observed. Its qualities are shown to be in agreement with the predictions of theoretical models through comparison of experimental and simulated images of a set of plastic wires of differing composition and size. Finally, we display an application of the technique to a biological sample, confirming the possibility of time-resolved imaging on the picosecond scale. (C) 2010 American Institute of Physics. [doi:10.1063/1.3491430]