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Early Diagnosis of Gaucher Disease and ASMD in Sardinia: The "Ichnos" Project

Gaucher disease (GD) and Acid Sphingomyelinase Deficiency (ASMD) are autosomal recessive lysosomal storage disorders (LSDs) caused by biallelic pathogenic variants in GBA1 and SMPD1, respectively. The resulting enzymatic defects lead to progressive accumulation of undegraded sphingolipids within macrophages and parenchymal cells, producing chronic, multisystemic, and often irreversible organ damage.

Real-world evaluation of health-related quality of life in hematology patients treated with rituximab: results of a multicentric cross-sectional cohort study

Background: Advancements in treating hematologic malignancies have improved survival, but health-related quality of life (HRQoL) remains a key concern due to the physical, emotional, and social impact of disease and treatment. Aims: This study aimed to assess HRQoL in patients undergoing treatment for hematologic malignancies, identifying the most affected domains to guide supportive interventions. Methods: HRQoL was evaluated using the 42-item Functional Assessment of Cancer Therapy–Lymphoma...

A Real-Life Multicenter Study of Checkpoint Inhibitors in Relapsed/Refractory Primary Mediastinal B-Cell Lymphoma

The use of immune checkpoint inhibitors (ICIs) has deeply improved the outcome of relapsed or refractory (R/R) primary mediastinal B-cell lymphoma (PMBCL) patients. However, real-world data are still limited, and several aspects, including the need for consolidation strategies, remain to be fully elucidated. We report the results of the multicenter Italian retrospective observational PRIMICI study on R/R PMBCL patients treated with ICIs in a real-life (off-label) setting. Seventy-four patient...

Valorization of Canola Leaves (Brassica napus L.) Through Sourdough Breadmaking: A Preliminary Study on Dough Rheology and Bread Quality

Canola seeds are largely used for oil extraction, while the rest of the plant, particularly the leaves, remain an underutilized yet unexplored functional food ingredient. The aim of this study is to investigate the upcycling of canola leaves powder (CL) to develop wheat bread with an increased potential nutritional value. The impact of including 5 g/100 g CL in combination with 20 g/100 g freeze-dried sourdough (flour weight basis) was investigated on the technological and...

Development, Characterization, and Exploitation in Food Systems of Functional Ingredients Obtained from Artichoke By-Products Phenolic Extracts

The study aimed to assess the technological properties of six ethanolic phenolic-rich extracts derived from artichoke bracts, stems, and leaves using different extraction methods (maceration and ultrasonic-assisted extraction—UAE) for the formulation of oil-in-water emulsions in which pea protein concentrate served as an emulsifier. To this aim, the extracts were tested for their surface properties and their effect on the colloidal and antioxidant properties in emulsions. The extracts reduced...

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