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Evaluating the efficacy of Rose Bengal-PVA combinations within PCL/PLA implants for sustained cancer treatment

The current investigation aims to address the limitations of conventional cancer therapy by developing an advanced, long-term drug delivery system using biocompatible Rose Bengal (RB)-loaded polyvinyl alcohol (PVA) matrices incorporated into 3D printed polycaprolactone (PCL) and polylactic acid (PLA) implants. The anticancer drug RB's high solubility and low lipophilicity require frequent and painful administration to the tumour site, limiting its clinical application. In this study, RB was e...

Invasion success on European coastal dunes

Many invasive plants are threatening the already highly vulnerable habitats of coastal dunes in Europe. Setting priority target species to control is mandatory for an effective planning of invasion management strategies at European level. This can be possible after iden- tifying the species that currently have greater invasion success, in consideration of their ecological traits and origin. We quantified the three main components of invasion success for the extra-European alien plants found o...

Bioclimatic pattern in a Mediterranean mountain area: assessment from a classification approach on a regional scale

The present work analyses the main weather patterns over the period 1981-2010 in the Central Apennines (Italy), drawing upon data from 23 monitoring stations spanning a wide elevation range (260-1750 m asl). Cluster analysis was used to identify homogeneous units and to verify the effectiveness of the bioclimatic classification by crossing the results derived from the application of hierarchical and non-hierarchical classification techniques. The results reveal a diversified picture of five c...

Exploring temporal trends of plant invasion in mediterranean coastal dunes

Alien plants represent a significant threat to species diversity and composition in natural habitats. Nevertheless, little is known about the dynamic of the invasion process and how its effects on native species change over time. In this study, we explored vegetation changes that occurred in invaded coastal dune habitats over the last 10-15 years (2005-2020), particularly addressing impacts on alien and diagnostic species. To monitor temporal trends, we used data resulting from a revisitation...

Integrating UAV imagery and machine learning via Geographic Object Based Image Analysis (GEOBIA) for enhanced monitoring of Yucca gloriosa in Mediterranean coastal dunes

Effective monitoring and early detection of invasive alien plant species (IAPs) are crucial for mitigating their spread and safeguarding native habitats. Unmanned Aerial Vehicles (UAVs) offer a cost-efficient solution, providing high resolution images. In this study, we aimed to develop a semi-automated methodology using a machine learning algorithm, spatial metrics, and clustering techniques on UAV images to monitor, map, and suggest management measures to counteract Yucca gloriosa, an invas...

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