Retrovirus-like particles containing the multiple sclerosis-associated retrovirus RNA, significantly found in the cerebrospinal fluid of patients with multiple sclerosis, have been preliminarily associated with a short-term poor clinical and radiological prognosis of the disease. We asked whether these prognostic indications are still measurable after a long-term clinical evaluation (10 years). Our 10-year blind observational study confirms that the presence of multiple sclerosis-associated retrovirus in the cerebrospinal fluid of early multiple sclerosis patients is associated with a significantly greater rate of relapse-unrelated unremitting disability and secondary progression of the disease.

Retrovirus-like particles containing the multiple sclerosis-associated retrovirus RNA, significantly found in the cerebrospinal fluid of patients with multiple sclerosis, have been preliminarily associated with a short-term poor clinical and radiological prognosis of the disease. We asked whether these prognostic indications are still measurable after a long-term clinical evaluation (10 years). Our 10-year blind observational study confirms that the presence of multiple sclerosis-associated retrovirus in the cerebrospinal fluid of early multiple sclerosis patients is associated with a significantly greater rate of relapse-unrelated unremitting disability and secondary progression of the disease.

Multiple sclerosis-associated retrovirus and progressive disability of multiple sclerosis / Sotgiu, Stefano; Mameli, Giuseppe; Serra, Caterina; Zarbo, Ir; Arru, Giannina; Dolei, Antonina. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - 16:10(2010), pp. 1248-1251. [10.1177/1352458510376956]

Multiple sclerosis-associated retrovirus and progressive disability of multiple sclerosis

SOTGIU, Stefano;MAMELI, Giuseppe;SERRA, Caterina;Zarbo IR;ARRU, Giannina;DOLEI, Antonina
2010

Abstract

Retrovirus-like particles containing the multiple sclerosis-associated retrovirus RNA, significantly found in the cerebrospinal fluid of patients with multiple sclerosis, have been preliminarily associated with a short-term poor clinical and radiological prognosis of the disease. We asked whether these prognostic indications are still measurable after a long-term clinical evaluation (10 years). Our 10-year blind observational study confirms that the presence of multiple sclerosis-associated retrovirus in the cerebrospinal fluid of early multiple sclerosis patients is associated with a significantly greater rate of relapse-unrelated unremitting disability and secondary progression of the disease.
Retrovirus-like particles containing the multiple sclerosis-associated retrovirus RNA, significantly found in the cerebrospinal fluid of patients with multiple sclerosis, have been preliminarily associated with a short-term poor clinical and radiological prognosis of the disease. We asked whether these prognostic indications are still measurable after a long-term clinical evaluation (10 years). Our 10-year blind observational study confirms that the presence of multiple sclerosis-associated retrovirus in the cerebrospinal fluid of early multiple sclerosis patients is associated with a significantly greater rate of relapse-unrelated unremitting disability and secondary progression of the disease.
Multiple sclerosis-associated retrovirus and progressive disability of multiple sclerosis / Sotgiu, Stefano; Mameli, Giuseppe; Serra, Caterina; Zarbo, Ir; Arru, Giannina; Dolei, Antonina. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - 16:10(2010), pp. 1248-1251. [10.1177/1352458510376956]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/61770
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