Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothieno- cycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives ␣␣ and ␣␣ were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively.
Synthesis and cytotoxicity of novel hexahydrothienocyclohepta-pyridazinone derivatives / Pau, A., Murineddu, G., Asproni, B., Murruzzu, C., Grella, G.E., Pinna, G.A., Curzu, M.M., Marchesi, I., Bagella, L.M.. - In: MOLECULES. - ISSN 1420-3049. - 14:9(2009), pp. 3494-3508. [10.3390/molecules14093494]
Synthesis and cytotoxicity of novel hexahydrothienocyclohepta-pyridazinone derivatives
PAU, Amedeo;MURINEDDU, Gabriele;ASPRONI, Battistina;GRELLA, Giuseppe Enrico;PINNA, Gerard Aime;CURZU, Maria Michela;BAGELLA, Luigi Marco
2009-01-01
Abstract
Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothieno- cycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives ␣␣ and ␣␣ were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
