Background: Tetanus is a non-communicable disease, preventable with vaccination. Despite the implemented vaccination strategy, a certain number of tetanus cases per year continue to occur. The aim of the study was to evaluate the seroprevalence of anti-tetanus antibodies in the Italian population by age, sex and geographical area. Methods: To determine the level of tetanus-specific antibodies, an immunoenzymatic assay was used. Results: A total of 3,821 serum samples were collected in the years 2019–20 from healthy subjects aged 6–90 years residing in 13 Italian regions. Overall, 85 % of the tested subjects resulted positive. The rate of subjects protected against tetanus showed a gradual decrease from the younger age groups to the older ones (6–12 years: 93.6 %, 13–24 years: 91.8 %, 25–39 years: 91.0 %, 40–64 years: 78.2 %, ≥ 65 years: 45.3 %); this is particularly evident in the Southern regions and Islands. Moreover, the prevalence of subjects with low protection (<0.1 IU/ml) was significantly higher in the ≥ 65 age group (10.3 %). Males and females’ prevalence showed a significant difference only in the oldest age group (M: 60.8 %, F: 30.4 %). In general, a higher prevalence was observed for Northern (90.8 %) and Central regions (87.3 %) than Southern regions and Islands (80.0 %). Conclusion: These data, compared with epidemiological ones which showed a high number of cases in the elderly, confirmed that the population with lower protection has a greater risk of contracting the disease, demonstrating the need for adequate immunization through both primary vaccination and boosters for all ages and both sexes, in order to provide lifelong protection.

Seroprotection against tetanus in the Italian general population / Bagordo, F.; Grassi, T.; Rota, M. C.; Castiglia, P.; Baldovin, T.; Della Polla, G.; Panico, A.; Ogliastro, M.; Marchi, S.; Vicentini, C.; Immordino, P.; Savio, M.; Gabutti, G.; Bordino, V.; Garlasco, J.; Memoli, G.; Giandomenico, A.; Greco, F.; Manini, I.; Montomoli, E.; Trombetta, C. M.; Baldo, V.; De Fino, M.; Marandola, M.; Giberti, I.; Orsi, A.; Barrocci, S.; La Porta, R.; Arghittu, A.; Dettori, M.; Boni, M.; Ghisellini, S.; Maida, C. M.; Tramuto, F.; Vitale, F.; Gamper, A.; Robatscher, E.; Guido, M.; Idolo, A.; Angelillo, I. F.; Napolitano, F.. - In: VACCINE. - ISSN 0264-410X. - (2024). [10.1016/j.vaccine.2024.05.015]

Seroprotection against tetanus in the Italian general population

Castiglia P.;Arghittu A.;Dettori M.;
2024-01-01

Abstract

Background: Tetanus is a non-communicable disease, preventable with vaccination. Despite the implemented vaccination strategy, a certain number of tetanus cases per year continue to occur. The aim of the study was to evaluate the seroprevalence of anti-tetanus antibodies in the Italian population by age, sex and geographical area. Methods: To determine the level of tetanus-specific antibodies, an immunoenzymatic assay was used. Results: A total of 3,821 serum samples were collected in the years 2019–20 from healthy subjects aged 6–90 years residing in 13 Italian regions. Overall, 85 % of the tested subjects resulted positive. The rate of subjects protected against tetanus showed a gradual decrease from the younger age groups to the older ones (6–12 years: 93.6 %, 13–24 years: 91.8 %, 25–39 years: 91.0 %, 40–64 years: 78.2 %, ≥ 65 years: 45.3 %); this is particularly evident in the Southern regions and Islands. Moreover, the prevalence of subjects with low protection (<0.1 IU/ml) was significantly higher in the ≥ 65 age group (10.3 %). Males and females’ prevalence showed a significant difference only in the oldest age group (M: 60.8 %, F: 30.4 %). In general, a higher prevalence was observed for Northern (90.8 %) and Central regions (87.3 %) than Southern regions and Islands (80.0 %). Conclusion: These data, compared with epidemiological ones which showed a high number of cases in the elderly, confirmed that the population with lower protection has a greater risk of contracting the disease, demonstrating the need for adequate immunization through both primary vaccination and boosters for all ages and both sexes, in order to provide lifelong protection.
2024
Seroprotection against tetanus in the Italian general population / Bagordo, F.; Grassi, T.; Rota, M. C.; Castiglia, P.; Baldovin, T.; Della Polla, G.; Panico, A.; Ogliastro, M.; Marchi, S.; Vicentini, C.; Immordino, P.; Savio, M.; Gabutti, G.; Bordino, V.; Garlasco, J.; Memoli, G.; Giandomenico, A.; Greco, F.; Manini, I.; Montomoli, E.; Trombetta, C. M.; Baldo, V.; De Fino, M.; Marandola, M.; Giberti, I.; Orsi, A.; Barrocci, S.; La Porta, R.; Arghittu, A.; Dettori, M.; Boni, M.; Ghisellini, S.; Maida, C. M.; Tramuto, F.; Vitale, F.; Gamper, A.; Robatscher, E.; Guido, M.; Idolo, A.; Angelillo, I. F.; Napolitano, F.. - In: VACCINE. - ISSN 0264-410X. - (2024). [10.1016/j.vaccine.2024.05.015]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/330869
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