In 2014, UNAIDS launched renewed global targets for HIV control to achieve by 2025, known as "the three 95": 95% of people living with HIV (PWH) diagnosed, of which 95% are receiving treatment, of which 95% are on sustained virological suppression. In Italy, new HIV diagnoses have been steadily decreasing since 2012. However, in 2020, 41% of new diagnoses presented with less than 200 CD4+ cells/mu L and 60% with less than 350 CD4+ cells/mu L. Implementing testing and early treatment is a key strategy to prevent AIDS, late presentation, and HIV transmission. We selected non-Infectious Diseases Units based on the European project HIDES and engaged colleagues in a condition-guided HIV screening strategy. We enrolled 300 patients, of which 202 were males (67.3%) and 98 were females (32.7%). Most of the screening was performed in Infectious Diseases (ID) and Hematologic wards. In total, we diagnosed eleven new HIV infections with a hospital prevalence in the study population of 3.7%. Five (45.4%) had a CD4 count <100/mm(3), one (9.1%) <200/mm(3), and one (9.1%) <300/mm(3). Regarding risk factors, 81.8% declared having had unprotected sexual intercourse and 54.5% were heterosexual. All patients promptly started a combination antiretroviral regimen and 10 (90.9%) obtained an undetectable HIV-RNA status. Eight of the eleven (72.7%) patients are currently on follow-up in our outpatient clinic. A proactive indicator disease-guided screening can help avoid missed opportunities to diagnose HIV infection in a hospital setting. Implementing this kind of intervention could favor early diagnosis and access to treatment.

HIV Infection Indicator Disease-Based Active Case Finding in a University Hospital: Results from the SHOT Project / De Vito, Andrea; Colpani, Agnese; Mameli, Maria Sabrina; Bagella, Paola; Fiore, Vito; Fozza, Claudio; Montesu, Maria Antonia; Fois, Alessandro Giuseppe; Filigheddu, Fabiana; Manzoni, Noemi; Putzu, Carlo; Babudieri, Sergio; Madeddu, Giordano. - In: INFECTIOUS DISEASE REPORTS. - ISSN 2036-7430. - 15:1(2023), pp. 94-101. [10.3390/idr15010010]

HIV Infection Indicator Disease-Based Active Case Finding in a University Hospital: Results from the SHOT Project

De Vito, Andrea;Colpani, Agnese;Mameli, Maria Sabrina;Bagella, Paola;Fiore, Vito;Fozza, Claudio;Montesu, Maria Antonia;Fois, Alessandro Giuseppe;Filigheddu, Fabiana;Putzu, Carlo;Babudieri, Sergio;Madeddu, Giordano
2023-01-01

Abstract

In 2014, UNAIDS launched renewed global targets for HIV control to achieve by 2025, known as "the three 95": 95% of people living with HIV (PWH) diagnosed, of which 95% are receiving treatment, of which 95% are on sustained virological suppression. In Italy, new HIV diagnoses have been steadily decreasing since 2012. However, in 2020, 41% of new diagnoses presented with less than 200 CD4+ cells/mu L and 60% with less than 350 CD4+ cells/mu L. Implementing testing and early treatment is a key strategy to prevent AIDS, late presentation, and HIV transmission. We selected non-Infectious Diseases Units based on the European project HIDES and engaged colleagues in a condition-guided HIV screening strategy. We enrolled 300 patients, of which 202 were males (67.3%) and 98 were females (32.7%). Most of the screening was performed in Infectious Diseases (ID) and Hematologic wards. In total, we diagnosed eleven new HIV infections with a hospital prevalence in the study population of 3.7%. Five (45.4%) had a CD4 count <100/mm(3), one (9.1%) <200/mm(3), and one (9.1%) <300/mm(3). Regarding risk factors, 81.8% declared having had unprotected sexual intercourse and 54.5% were heterosexual. All patients promptly started a combination antiretroviral regimen and 10 (90.9%) obtained an undetectable HIV-RNA status. Eight of the eleven (72.7%) patients are currently on follow-up in our outpatient clinic. A proactive indicator disease-guided screening can help avoid missed opportunities to diagnose HIV infection in a hospital setting. Implementing this kind of intervention could favor early diagnosis and access to treatment.
2023
HIV Infection Indicator Disease-Based Active Case Finding in a University Hospital: Results from the SHOT Project / De Vito, Andrea; Colpani, Agnese; Mameli, Maria Sabrina; Bagella, Paola; Fiore, Vito; Fozza, Claudio; Montesu, Maria Antonia; Fois, Alessandro Giuseppe; Filigheddu, Fabiana; Manzoni, Noemi; Putzu, Carlo; Babudieri, Sergio; Madeddu, Giordano. - In: INFECTIOUS DISEASE REPORTS. - ISSN 2036-7430. - 15:1(2023), pp. 94-101. [10.3390/idr15010010]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/306367
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