Certain bacteria constitute a threat to humans due to their ability to escape host defenses as they easily develop drug resistance. Bacteria are classified into gram-positive and gram-negative according to the composition of the cell membrane structure. Gram-negative bacteria have an additional outer membrane (OM) that is not present in their gram-positive counterpart; the latter instead hold a thicker peptidoglycan (PG) layer. This review covers the main structural and functional properties of cell wall polysaccharides (CWPs) and PG. Drugs targeting CWPs are discussed, both noncarbohydrate-related (beta-lactams, fosfomycin, and lipopeptides) and carbohydrate-related (glycopeptides and lipoglycopeptides). Bacterial resistance to these drugs continues to evolve, which calls for novel antibacterial approaches to be developed. The use of carbohydrate-based vaccines as a valid strategy to prevent bacterial infections is also addressed.

Antibiotics and Carbohydrate-Containing Drugs Targeting Bacterial Cell Envelopes: An Overview / Riu, Federico; Ruda, Alessandro; Ibba, Roberta; Sestito, Simona; Lupinu, Ilenia; Piras, Sandra; Widmalm, Göran; Carta, Antonio. - In: PHARMACEUTICALS. - ISSN 1424-8247. - 15:8(2022), p. 942. [10.3390/ph15080942]

Antibiotics and Carbohydrate-Containing Drugs Targeting Bacterial Cell Envelopes: An Overview

Riu, Federico
Membro del Collaboration Group
;
Ibba, Roberta
Membro del Collaboration Group
;
Sestito, Simona
Membro del Collaboration Group
;
Lupinu, Ilenia;Piras, Sandra;Carta, Antonio
Supervision
2022-01-01

Abstract

Certain bacteria constitute a threat to humans due to their ability to escape host defenses as they easily develop drug resistance. Bacteria are classified into gram-positive and gram-negative according to the composition of the cell membrane structure. Gram-negative bacteria have an additional outer membrane (OM) that is not present in their gram-positive counterpart; the latter instead hold a thicker peptidoglycan (PG) layer. This review covers the main structural and functional properties of cell wall polysaccharides (CWPs) and PG. Drugs targeting CWPs are discussed, both noncarbohydrate-related (beta-lactams, fosfomycin, and lipopeptides) and carbohydrate-related (glycopeptides and lipoglycopeptides). Bacterial resistance to these drugs continues to evolve, which calls for novel antibacterial approaches to be developed. The use of carbohydrate-based vaccines as a valid strategy to prevent bacterial infections is also addressed.
2022
Antibiotics and Carbohydrate-Containing Drugs Targeting Bacterial Cell Envelopes: An Overview / Riu, Federico; Ruda, Alessandro; Ibba, Roberta; Sestito, Simona; Lupinu, Ilenia; Piras, Sandra; Widmalm, Göran; Carta, Antonio. - In: PHARMACEUTICALS. - ISSN 1424-8247. - 15:8(2022), p. 942. [10.3390/ph15080942]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/301890
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