The aim of this retrospective study, conducted in an Italian tertiary care hospital, was to evaluate maternal-fetal and neonatal clinical outcomes in a group of patients with pregestational diabetes mellitus (PGDM), such as diabetes mellitus type 1 (DM1), diabetes mellitus type 2 (DM2), and maturity onset diabetes of the young (MODY). Overall, 174 pregnant women, nulliparous and multiparous, with a single pregnancy were enrolled. Data on pregnancy, childbirth, and new-borns were collected from medical records. The selected patients were divided into two groups: the PGDM group (42 with DM1, 14 with DM2, and 2 with MODY), and the control group (116 patients with a negative pathological history of diabetes mellitus). We reported an incidence of preterm delivery of 55.2% in the PGDM group, including 59.5% of those with DM1 and 42.9% of those with DM2, vs. 6% in the controls. Fetal growth disorders, such as intrauterine growth re-tardation, small for gestational age, and fetal macrosomia were found in 19% and 3.6% in the case and control groups, respectively. A relationship between DM2 and gestational hypertension was found.

Fetal Growth and Neonatal Outcomes in Pregestational Diabetes Mellitus in a Population with a High Prevalence of Diabetes / Capobianco, Giampiero; Gulotta, Alessandra; Tupponi, Giulio; Dessole, Francesco; Virdis, Giuseppe; Cherchi, Claudio; De Vita, Davide; Petrillo, Marco; Olzai, Mauro Giorgio; Antonucci, Roberto; Saderi, Laura; Cherchi, Pier Luigi; Dessole, Salvatore; Sotgiu, Giovanni. - In: JOURNAL OF PERSONALIZED MEDICINE. - ISSN 2075-4426. - 12:1320(2022), pp. 1-9. [10.3390/jpm12081320]

Fetal Growth and Neonatal Outcomes in Pregestational Diabetes Mellitus in a Population with a High Prevalence of Diabetes

Giampiero Capobianco
Writing – Original Draft Preparation
;
Alessandra Gulotta
Writing – Original Draft Preparation
;
Giulio Tupponi
Formal Analysis
;
Francesco Dessole
Resources
;
Giuseppe Virdis
Validation
;
Claudio Cherchi
Data Curation
;
Marco Petrillo
Writing – Review & Editing
;
Giorgio Olzai
Writing – Review & Editing
;
Roberto Antonucci
Validation
;
Laura Saderi
Investigation
;
Pier Luigi Cherchi
Conceptualization
;
Salvatore Dessole
Writing – Review & Editing
;
Giovanni Sotgiu
Writing – Original Draft Preparation
2022

Abstract

The aim of this retrospective study, conducted in an Italian tertiary care hospital, was to evaluate maternal-fetal and neonatal clinical outcomes in a group of patients with pregestational diabetes mellitus (PGDM), such as diabetes mellitus type 1 (DM1), diabetes mellitus type 2 (DM2), and maturity onset diabetes of the young (MODY). Overall, 174 pregnant women, nulliparous and multiparous, with a single pregnancy were enrolled. Data on pregnancy, childbirth, and new-borns were collected from medical records. The selected patients were divided into two groups: the PGDM group (42 with DM1, 14 with DM2, and 2 with MODY), and the control group (116 patients with a negative pathological history of diabetes mellitus). We reported an incidence of preterm delivery of 55.2% in the PGDM group, including 59.5% of those with DM1 and 42.9% of those with DM2, vs. 6% in the controls. Fetal growth disorders, such as intrauterine growth re-tardation, small for gestational age, and fetal macrosomia were found in 19% and 3.6% in the case and control groups, respectively. A relationship between DM2 and gestational hypertension was found.
Fetal Growth and Neonatal Outcomes in Pregestational Diabetes Mellitus in a Population with a High Prevalence of Diabetes / Capobianco, Giampiero; Gulotta, Alessandra; Tupponi, Giulio; Dessole, Francesco; Virdis, Giuseppe; Cherchi, Claudio; De Vita, Davide; Petrillo, Marco; Olzai, Mauro Giorgio; Antonucci, Roberto; Saderi, Laura; Cherchi, Pier Luigi; Dessole, Salvatore; Sotgiu, Giovanni. - In: JOURNAL OF PERSONALIZED MEDICINE. - ISSN 2075-4426. - 12:1320(2022), pp. 1-9. [10.3390/jpm12081320]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/295403
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