Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver tumor with increasing incidence worldwide, dismal prognosis, and few therapeutic options. Mounting evidence underlines the role of the Hippo pathway in this disease; however, the molecular mechanisms whereby the Hippo cascade contributes to cholangiocarcinogenesis remain poorly defined.

The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease / Cigliano, Antonio; Zhang, Shanshan; Ribback, Silvia; Steinmann, Sara; Sini, Marcella; Ament, Cindy E; Utpatel, Kirsten; Song, Xinhua; Wang, Jingxiao; Pilo, Maria G; Berger, Fabian; Wang, Haichuan; Tao, Junyan; Li, Xiaolei; Pes, Giovanni M; Mancarella, Serena; Giannelli, Gianluigi; Dombrowski, Frank; Evert, Matthias; Calvisi, Diego F; Chen, Xin; Evert, Katja. - In: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. - ISSN 1756-9966. - 41:1(2022), p. 192. [10.1186/s13046-022-02394-2]

The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease

Cigliano, Antonio;Pilo, Maria G;Pes, Giovanni M;Calvisi, Diego F;
2022-01-01

Abstract

Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver tumor with increasing incidence worldwide, dismal prognosis, and few therapeutic options. Mounting evidence underlines the role of the Hippo pathway in this disease; however, the molecular mechanisms whereby the Hippo cascade contributes to cholangiocarcinogenesis remain poorly defined.
2022
Inglese
41
1
192
AKT; Hippo pathway; Intrahepatic cholangiocarcinoma; Notch; TAZ; TEAD transcription factors; Adaptor Proteins, Signal Transducing; Animals; Bile Ducts, Intrahepatic; Hippo Signaling Pathway; Humans; Mice; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; YAP-Signaling Proteins; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Cholangiocarcinoma
Cigliano, Antonio; Zhang, Shanshan; Ribback, Silvia; Steinmann, Sara; Sini, Marcella; Ament, Cindy E; Utpatel, Kirsten; Song, Xinhua; Wang, Jingxiao; ...espandi
The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease / Cigliano, Antonio; Zhang, Shanshan; Ribback, Silvia; Steinmann, Sara; Sini, Marcella; Ament, Cindy E; Utpatel, Kirsten; Song, Xinhua; Wang, Jingxiao; Pilo, Maria G; Berger, Fabian; Wang, Haichuan; Tao, Junyan; Li, Xiaolei; Pes, Giovanni M; Mancarella, Serena; Giannelli, Gianluigi; Dombrowski, Frank; Evert, Matthias; Calvisi, Diego F; Chen, Xin; Evert, Katja. - In: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. - ISSN 1756-9966. - 41:1(2022), p. 192. [10.1186/s13046-022-02394-2]
info:eu-repo/semantics/article
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/294107
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