Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver tumor with increasing incidence worldwide, dismal prognosis, and few therapeutic options. Mounting evidence underlines the role of the Hippo pathway in this disease; however, the molecular mechanisms whereby the Hippo cascade contributes to cholangiocarcinogenesis remain poorly defined.

The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease / Cigliano, Antonio; Zhang, Shanshan; Ribback, Silvia; Steinmann, Sara; Sini, Marcella; Ament, Cindy E; Utpatel, Kirsten; Song, Xinhua; Wang, Jingxiao; Pilo, Maria G; Berger, Fabian; Wang, Haichuan; Tao, Junyan; Li, Xiaolei; Pes, Giovanni M; Mancarella, Serena; Giannelli, Gianluigi; Dombrowski, Frank; Evert, Matthias; Calvisi, Diego F; Chen, Xin; Evert, Katja. - In: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. - ISSN 1756-9966. - 41:1(2022), p. 192. [10.1186/s13046-022-02394-2]

The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease

Cigliano, Antonio;Pilo, Maria G;Pes, Giovanni M;Calvisi, Diego F;
2022

Abstract

Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver tumor with increasing incidence worldwide, dismal prognosis, and few therapeutic options. Mounting evidence underlines the role of the Hippo pathway in this disease; however, the molecular mechanisms whereby the Hippo cascade contributes to cholangiocarcinogenesis remain poorly defined.
The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease / Cigliano, Antonio; Zhang, Shanshan; Ribback, Silvia; Steinmann, Sara; Sini, Marcella; Ament, Cindy E; Utpatel, Kirsten; Song, Xinhua; Wang, Jingxiao; Pilo, Maria G; Berger, Fabian; Wang, Haichuan; Tao, Junyan; Li, Xiaolei; Pes, Giovanni M; Mancarella, Serena; Giannelli, Gianluigi; Dombrowski, Frank; Evert, Matthias; Calvisi, Diego F; Chen, Xin; Evert, Katja. - In: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. - ISSN 1756-9966. - 41:1(2022), p. 192. [10.1186/s13046-022-02394-2]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/294107
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