Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2; p<0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had no adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p<0.001). Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic.
Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic / Bogani, Giorgio; Scambia, Giovanni; Cimmino, Chiara; Fanfani, Francesco; Costantini, Barbara; Loverro, Matteo; Ferrandina, Gabriella; Landoni, Fabio; Bazzurini, Luca; Grassi, Tommaso; Vitobello, Domenico; Siesto, Gabriele; Perrone, Anna Myriam; Zanagnolo, Vanna; De Iaco, Pierandrea; Multinu, Francesco; Ghezzi, Fabio; Casarin, Jvan; Berretta, Roberto; Capozzi, Vito A; Zupi, Errico; Centini, Gabriele; Pellegrino, Antonio; Corso, Silvia; Stevenazzi, Guido; Montoli, Serena; Boschi, Anna Chiara; Comerci, Giuseppe; Greco, Pantaleo; Martinello, Ruby; Sopracordevole, Francesco; Giorda, Giorgio; Simoncini, Tommaso; Caretto, Marta; Sartori, Enrico; Ferrari, Federico; Cianci, Antonio; Sarpietro, Giuseppe; Matarazzo, Maria Grazia; Zullo, Fulvio; Bifulco, Giuseppe; Morelli, Michele; Ferrero, Annamaria; Biglia, Nicoletta; Barra, Fabio; Ferrero, Simone; Leone Roberti Maggiore, Umberto; Cianci, Stefano; Chiantera, Vito; Ercoli, Alfredo; Sozzi, Giulio; Martoccia, Angela; Schettini, Sergio; Orlando, Teresa; Cannone, Francesco G; Ettore, Giuseppe; Puppo, Andrea; Borghese, Martina; Martinelli, Canio; Muzii, Ludovico; Di Donato, Violante; Driul, Lorenza; Restaino, Stefano; Bergamini, Alice; Candotti, Giorgio; Bocciolone, Luca; Plotti, Francesco; Angioli, Roberto; Mantovani, Giulia; Ceccaroni, Marcello; Cassani, Chiara; Dominoni, Mattia; Giambanco, Laura; Amodeo, Silvia; Leo, Livio; Thomasset, Raphael; Raimondo, Diego; Seracchioli, Renato; Malzoni, Mario; Gorlero, Franco; Di Luca, Martina; Busato, Enrico; Kilzie, Sami; Dell'Acqua, Andrea; Scarfone, Giovanna; Vercellini, Paolo; Petrillo, Marco; Dessole, Salvatore; Capobianco, Giampiero; Ciavattini, Andrea; Delli Carpini, Giovanni; Giannella, Luca; Mereu, Liliana; Tateo, Saverio; Sorbi, Flavia; Fambrini, Massimiliano; Cicogna, Stefania; Romano, Federico; Ricci, Giuseppe; Trojano, Giuseppe; Consonni, Roberto; Cantaluppi, Simona; Lippolis, Antonio; Tinelli, Raffaele; D'Ippolito, Giovanni; Aguzzoli, Lorenzo; Mandato, Vincenzo D; Palomba, Stefano; Calandra, Davide; Rosati, Maurizio; Gallo, Cinzia; Surico, Daniela; Remorgida, Valentino; Ruscitto, Francesco; Beretta, Paolo; Benedetti Panici, Pierluigi; Raspagliesi, Francesco. - In: JOURNAL OF GYNECOLOGIC ONCOLOGY. - ISSN 2005-0380. - 33:1(2022), p. e10. [10.3802/jgo.2022.33.e10]
Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic
Petrillo, MarcoWriting – Original Draft Preparation
;Dessole, SalvatoreWriting – Review & Editing
;Capobianco, GiampieroWriting – Review & Editing
;
2022-01-01
Abstract
Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2; p<0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had no adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p<0.001). Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
