CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishThis paper describes the enantioselective synthesis of analogues of sapinofuranones A and B, namely 5-substitutes dihydro- and 5H-furan-ones, and their in vitro growth inhibitory activity against six cancer cell lines in comparison with fungal furanones such as diplofuranone A, diplobifuranylones A and B, as well as (S,S)-enantiomer of sapinofuranone B. The compounds under study displayed weak if any in vitro growth inhibitory activity against the analysed cancer cell lines. However, it seems that among dihydro- and 5H-furan-ones bearing a 1-hydroxypentyl side chain, the stereochemistry of the furanone ring and that of hydroxylated methine could modify the in vitro growth activity of these compounds. The natural furanones that showed a different unsaturated chain at C-4 or rearranged into a dihydrofuran ring appeared to be inactive in terms of growth inhibitory activity, e.g. displaying growth inhibitory concentration at 50% (GI50) > 100 μM in all six cancer cell lines analysed.
Natural and synthetic furanones with anticancer activity / Cimmino A.; Scafato P; Mathieu V ; Ingels A ; D'Amico W ; Pisani L, .; Maddau L.; Superchi S ; Kiss R ; Evidente A. - In: NATURAL PRODUCT COMMUNICATIONS. - ISSN 1555-9475. - 11:10(2016), pp. 1471-1474.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
| Titolo: | Natural and synthetic furanones with anticancer activity | |
| Autori: | ||
| Data di pubblicazione: | 2016 | |
| Rivista: | ||
| Citazione: | Natural and synthetic furanones with anticancer activity / Cimmino A.; Scafato P; Mathieu V ; Ingels A ; D'Amico W ; Pisani L, .; Maddau L.; Superchi S ; Kiss R ; Evidente A. - In: NATURAL PRODUCT COMMUNICATIONS. - ISSN 1555-9475. - 11:10(2016), pp. 1471-1474. | |
| Handle: | http://hdl.handle.net/11388/174726 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11388/174726
Copyright © 2022