In Parkinson's disease (PD) ZnT proteins play an important role. Zinc is a co-factor of numerous enzymes and stabilizes the tertiary structure of several proteins. Nothing is known about previous infections mediated by Mycobacterium avium subsp. paratuberculosis (MAP). We evaluated if a previous infection with MAP could induce the production of antibodies that cross-reacted with the Znt homologous antigenic peptides associated to Parkinson. The humoral response toward MAP3865c peptides, ZnT3 and ZnT10 was evaluated. The hypothesis of cross-reactivity needs to be confirmed; we have observed the presence of MAP in PD patients by PCR, positivity to MAP3865c peptides, therefore MAP infection but not cross-reaction with human homologous Znt proteins.

Is there a role for Mycobacterium avium subspecies paratuberculosis in Parkinson's disease? / Arru, Giannina; Caggiu, Elisa; Paulus, Kai; Sechi, Gianpietro; Mameli, Giuseppe; Sechi, Leonardo Antonio. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 293:(2016), pp. 86-90. [10.1016/j.jneuroim.2016.02.016]

Is there a role for Mycobacterium avium subspecies paratuberculosis in Parkinson's disease?

ARRU, Giannina;CAGGIU, Elisa;SECHI, Gianpietro;MAMELI, Giuseppe;SECHI, Leonardo Antonio
2016-01-01

Abstract

In Parkinson's disease (PD) ZnT proteins play an important role. Zinc is a co-factor of numerous enzymes and stabilizes the tertiary structure of several proteins. Nothing is known about previous infections mediated by Mycobacterium avium subsp. paratuberculosis (MAP). We evaluated if a previous infection with MAP could induce the production of antibodies that cross-reacted with the Znt homologous antigenic peptides associated to Parkinson. The humoral response toward MAP3865c peptides, ZnT3 and ZnT10 was evaluated. The hypothesis of cross-reactivity needs to be confirmed; we have observed the presence of MAP in PD patients by PCR, positivity to MAP3865c peptides, therefore MAP infection but not cross-reaction with human homologous Znt proteins.
Is there a role for Mycobacterium avium subspecies paratuberculosis in Parkinson's disease? / Arru, Giannina; Caggiu, Elisa; Paulus, Kai; Sechi, Gianpietro; Mameli, Giuseppe; Sechi, Leonardo Antonio. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 293:(2016), pp. 86-90. [10.1016/j.jneuroim.2016.02.016]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/162338
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