Seventeen (un)substituted N-[4-(propyl)cyclohexyl]-amides (6a-h, 7a-h and 8) were synthesized and tested as anti-inflammatory and analgesic agents. The substituents on the aromatic ring were chosen in order to study the influence of electron-withdrawing or electron-donating residues, that change the electronic density on the aromatic moiety. The pharmacological results allow drawing some preliminary considerations on structure-activity relationships.

Synthesis of N-[4-propyl)cyclohexyl]-amides with Anti-Inflammatory and Analgesic Activities / Pau, A; Boatto, Gianpiero; Asproni, Battistina; Palomba, M; Auzzas, L; Cerri, R; Palagiano, F; Filippelli, W; Falcone, G; Motola, G.. - In: IL FARMACO. - ISSN 0014-827X. - 55:(2000), pp. 439-447. [10.1016/S0014-827X(00)00063-X]

Synthesis of N-[4-propyl)cyclohexyl]-amides with Anti-Inflammatory and Analgesic Activities

BOATTO, Gianpiero;ASPRONI, Battistina;PALOMBA M;
2000

Abstract

Seventeen (un)substituted N-[4-(propyl)cyclohexyl]-amides (6a-h, 7a-h and 8) were synthesized and tested as anti-inflammatory and analgesic agents. The substituents on the aromatic ring were chosen in order to study the influence of electron-withdrawing or electron-donating residues, that change the electronic density on the aromatic moiety. The pharmacological results allow drawing some preliminary considerations on structure-activity relationships.
Synthesis of N-[4-propyl)cyclohexyl]-amides with Anti-Inflammatory and Analgesic Activities / Pau, A; Boatto, Gianpiero; Asproni, Battistina; Palomba, M; Auzzas, L; Cerri, R; Palagiano, F; Filippelli, W; Falcone, G; Motola, G.. - In: IL FARMACO. - ISSN 0014-827X. - 55:(2000), pp. 439-447. [10.1016/S0014-827X(00)00063-X]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/86928
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 5
social impact