A new series of 3-isopropyl-, 3-trifluoromethyl- and 3-bromomethylquinoxaline-2-ones variously substituted on the benzo-moiety were synthesized and submitted to a preliminary in vitro evaluation for antibacterial, antifungal and anti-HIV activities. Furthermore, all compounds were also tested for cytotoxicity. Results of the screening showed that compound 10 exhibits moderate antimicrobial activity against Staphylococcus aureus (MIC=33 muM), and that 25 and 26 showed interesting cytotoxicity versus mock-infected MT-4 cells. All the other compounds were inactive. (C) 2002 Elsevier Science S.A. All rights reserved.
Synthesis and evaluation for biological actvity of 3-alkyl and 3-halogenoalkyl-quinoxalin-2-ones variously substituted. Part 4 / Carta, Antonio; Sanna, P; Loriga, M; Setzu, M. G.; LA COLLA, P; Loddo, R.. - In: IL FARMACO. - ISSN 0014-827X. - 57:(2002), pp. 19-25. [10.1016/S0014-827X(01)01153-3]
Synthesis and evaluation for biological actvity of 3-alkyl and 3-halogenoalkyl-quinoxalin-2-ones variously substituted. Part 4
CARTA, Antonio;
2002-01-01
Abstract
A new series of 3-isopropyl-, 3-trifluoromethyl- and 3-bromomethylquinoxaline-2-ones variously substituted on the benzo-moiety were synthesized and submitted to a preliminary in vitro evaluation for antibacterial, antifungal and anti-HIV activities. Furthermore, all compounds were also tested for cytotoxicity. Results of the screening showed that compound 10 exhibits moderate antimicrobial activity against Staphylococcus aureus (MIC=33 muM), and that 25 and 26 showed interesting cytotoxicity versus mock-infected MT-4 cells. All the other compounds were inactive. (C) 2002 Elsevier Science S.A. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
