Based on ESI-MS measurements, we show here that some representative cytotoxic gold(III) compounds produce stable adducts upon reaction with the copper chaperone Atox-1; notably, such adducts contain gold in the oxidation state +1. These findings are of interest to understand the intracellular metabolism of medicinal gold species and to develop new potent inhibitors of the copper trafficking system.

Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications / Gabbiani, C; Scaletti, F; Massai, L; Michelucci, E; Cinellu, Maria Agostina; Messori, L.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 48:(2012), pp. 11623-11625. [10.1039/c2cc36610j]

Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications

CINELLU, Maria Agostina;
2012-01-01

Abstract

Based on ESI-MS measurements, we show here that some representative cytotoxic gold(III) compounds produce stable adducts upon reaction with the copper chaperone Atox-1; notably, such adducts contain gold in the oxidation state +1. These findings are of interest to understand the intracellular metabolism of medicinal gold species and to develop new potent inhibitors of the copper trafficking system.
2012
Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications / Gabbiani, C; Scaletti, F; Massai, L; Michelucci, E; Cinellu, Maria Agostina; Messori, L.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 48:(2012), pp. 11623-11625. [10.1039/c2cc36610j]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/83953
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