Reduction of symmetrical intramolecular diarylmethyl ethers (3a and 8a) and amines (3b and 8b) with alkali metals in THF allows the generation of unsymmetrical oxy- or amino-functionalised arylmethyl organometallics. Such intermediates were successfully trapped with various electrophiles, allowing a new access to unsymmetrically 2,2'-disubstituted-1,1'-biaryls (5aa-5bf) and 1,8-disubstituted naphthalenes

Reductive Cleavage of Benzannelated Cyclic Ethers and Amines: Synthetic Applications / Azzena, Ugo Gavino; Salvatore, Demartis; Luciano, Pilo; Elisabetta, Piras. - In: TETRAHEDRON. - ISSN 0040-4020. - 56:(2000), pp. 8375-8382. [10.1016/S0040-4020(00)00783-3]

Reductive Cleavage of Benzannelated Cyclic Ethers and Amines: Synthetic Applications

AZZENA, Ugo Gavino;
2000-01-01

Abstract

Reduction of symmetrical intramolecular diarylmethyl ethers (3a and 8a) and amines (3b and 8b) with alkali metals in THF allows the generation of unsymmetrical oxy- or amino-functionalised arylmethyl organometallics. Such intermediates were successfully trapped with various electrophiles, allowing a new access to unsymmetrically 2,2'-disubstituted-1,1'-biaryls (5aa-5bf) and 1,8-disubstituted naphthalenes
2000
Reductive Cleavage of Benzannelated Cyclic Ethers and Amines: Synthetic Applications / Azzena, Ugo Gavino; Salvatore, Demartis; Luciano, Pilo; Elisabetta, Piras. - In: TETRAHEDRON. - ISSN 0040-4020. - 56:(2000), pp. 8375-8382. [10.1016/S0040-4020(00)00783-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/83767
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