A fatal case involving mepivacaine-induced epidural anesthesia is described. The pathological findings were typical of cardiac shock from ischemic origin. Cerebrospinal fluid (CSF) was obtained several hours after death and mepivacaine was identified by gas chromatography- mass spectrometry (GC-MS). Its concentration was determined by high performance liquid chromatography with diode array detection (HPLC–DAD). Extraction from CSF was performed by deproteinization with acetonitrile. The mepivacaine concentration in the sample was 264 lg ⁄ mL. Concentrations of mepivacaine in CSF following epidural anesthesia are not reported in literature to our knowledge. This is the first reported case of death in which the mepivacaine concentration in CSF has been determined.

HPLC-DAD determination of mepivacaina in cerebrospinal fluid from a fatal case / M., Nieddu; Boatto, Gianpiero; D., Serra; A., Soro; S., Lorenzoni; F., Lubinu. - In: JOURNAL OF FORENSIC SCIENCES. - ISSN 0022-1198. - 52 (5):5(2007), pp. 1223-1224. [10.1111/j.1556-4029.2007.00526.x]

HPLC-DAD determination of mepivacaina in cerebrospinal fluid from a fatal case

M. NIEDDU;BOATTO, Gianpiero;
2007

Abstract

A fatal case involving mepivacaine-induced epidural anesthesia is described. The pathological findings were typical of cardiac shock from ischemic origin. Cerebrospinal fluid (CSF) was obtained several hours after death and mepivacaine was identified by gas chromatography- mass spectrometry (GC-MS). Its concentration was determined by high performance liquid chromatography with diode array detection (HPLC–DAD). Extraction from CSF was performed by deproteinization with acetonitrile. The mepivacaine concentration in the sample was 264 lg ⁄ mL. Concentrations of mepivacaine in CSF following epidural anesthesia are not reported in literature to our knowledge. This is the first reported case of death in which the mepivacaine concentration in CSF has been determined.
HPLC-DAD determination of mepivacaina in cerebrospinal fluid from a fatal case / M., Nieddu; Boatto, Gianpiero; D., Serra; A., Soro; S., Lorenzoni; F., Lubinu. - In: JOURNAL OF FORENSIC SCIENCES. - ISSN 0022-1198. - 52 (5):5(2007), pp. 1223-1224. [10.1111/j.1556-4029.2007.00526.x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/83461
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