A number of 9H-indeno[2,1-c]pyridazine N-oxides (3a-c) and benzo[f]cinnoline N-oxides (4,5a-c) have been synthesized and :tested for antimicrobial activity. All new products were inactive against Cram negative bacteria and fungi. In contrast, among the compounds synthesized, 3b, 4b and 5b showed a moderate activity against Gram positive Staphylococcus aureus and Staphylocaccus epidermidis, Of the present series, the 9-nitro-benzo[f]cinnoline N-oxide 5b possessed the highest activity especially against Trichomonas vaginalis (MIC = 3.9 mug/ml).
Pyridazine N-Oxides. III. Synthesis and “in vitro” antimicrobial properties of N-Oxide derivatives based on tricyclic indeno[2,1-c]pyridazine and benzo [f]cinnoline systems / Gavini, Elisabetta; Juliano, Claudia Clelia Assunta; Mule, A.; Pirisino, G.; Murineddu, Gabriele; Pinna, Gerard Aime. - In: ARCHIV DER PHARMAZIE. - ISSN 0365-6233. - 333:10(2000), pp. 341-346. [10.1002/1521-4184(200010)333:10<341::AID-ARDP341>3.0.CO;2-U]
Pyridazine N-Oxides. III. Synthesis and “in vitro” antimicrobial properties of N-Oxide derivatives based on tricyclic indeno[2,1-c]pyridazine and benzo [f]cinnoline systems
GAVINI, Elisabetta;JULIANO, Claudia Clelia Assunta;MURINEDDU, Gabriele;PINNA, Gerard Aime
2000-01-01
Abstract
A number of 9H-indeno[2,1-c]pyridazine N-oxides (3a-c) and benzo[f]cinnoline N-oxides (4,5a-c) have been synthesized and :tested for antimicrobial activity. All new products were inactive against Cram negative bacteria and fungi. In contrast, among the compounds synthesized, 3b, 4b and 5b showed a moderate activity against Gram positive Staphylococcus aureus and Staphylocaccus epidermidis, Of the present series, the 9-nitro-benzo[f]cinnoline N-oxide 5b possessed the highest activity especially against Trichomonas vaginalis (MIC = 3.9 mug/ml).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
