A fully randomized double-blind study, stratified according to diagnosis, was carried out in order to assess the effect of endonasal neostigmine in the treatment of post-laparotic paralytic ileus. A total of 40 patients (16 M, 24 F), aged between 22 and 76 years old, were admitted to the study; of these 20 were cholecystectomized and 20 had undergone emergency surgery. According to a special randomization list, 10 patients from each pathological group were treated with 6% neostigmine en (1 puff = 5.4 mg) and the other ten were treated with placebo. Both treatments were administered at a dose of 2 puffs, one per nostril, at the end of surgery and then repeated every 4 hours up to a maximum of 6 puffs/day. Treatment was continued for 4 days or until canalization of feces and gas was achieved. The mean daily dose of endonasal neostigmine found to be efficacious was 4 puffs/day, equivalent to 24.7 mg in cholecystectomized patients and 23.5 mg in patients undergoing emergency surgery. In over-all terms the canalization of gas and feces was observed in 74% of patients treated with neostigmine and in 45% of those receiving placebo and the difference was statistically significant.

A double-blind study of neostigmine versus placebo in paralytic ileus as a result of surgical interventions / Orlando, E; Finelli, F; Colla, M; Giotto, E; Terragni, Pierpaolo; Olivero, G.. - In: MINERVA CHIRURGICA. - ISSN 0026-4733. - 49:5(1994), pp. 451-455.

A double-blind study of neostigmine versus placebo in paralytic ileus as a result of surgical interventions

TERRAGNI, Pierpaolo;
1994-01-01

Abstract

A fully randomized double-blind study, stratified according to diagnosis, was carried out in order to assess the effect of endonasal neostigmine in the treatment of post-laparotic paralytic ileus. A total of 40 patients (16 M, 24 F), aged between 22 and 76 years old, were admitted to the study; of these 20 were cholecystectomized and 20 had undergone emergency surgery. According to a special randomization list, 10 patients from each pathological group were treated with 6% neostigmine en (1 puff = 5.4 mg) and the other ten were treated with placebo. Both treatments were administered at a dose of 2 puffs, one per nostril, at the end of surgery and then repeated every 4 hours up to a maximum of 6 puffs/day. Treatment was continued for 4 days or until canalization of feces and gas was achieved. The mean daily dose of endonasal neostigmine found to be efficacious was 4 puffs/day, equivalent to 24.7 mg in cholecystectomized patients and 23.5 mg in patients undergoing emergency surgery. In over-all terms the canalization of gas and feces was observed in 74% of patients treated with neostigmine and in 45% of those receiving placebo and the difference was statistically significant.
1994
A double-blind study of neostigmine versus placebo in paralytic ileus as a result of surgical interventions / Orlando, E; Finelli, F; Colla, M; Giotto, E; Terragni, Pierpaolo; Olivero, G.. - In: MINERVA CHIRURGICA. - ISSN 0026-4733. - 49:5(1994), pp. 451-455.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/83150
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