We report two cases of duodenal ulcer (DU) identified at endoscopy in a pair of dizygotic twins; their outstanding clinically recognizable features were a very early onset, a great familiar occurrence, a lack of triggering conditions (drugs, burns, stress, sepsis, respiratory distress), normal serum levels of gastrin and pepsinogen I, inadequate response to medical treatment with H2-receptor antagonists, but satisfactory response to associated therapy with H2-receptor antagonists and sucralfate. Results of this study show that examined twins were affected by a form of early-onset primary DU, probably inherited like an autosomal dominant disorder with high degree of penetrance, associated with normal serum pepsinogen I and gastrin; in this form of Du a decreased tissue resistance of duodenal mucosa is likely more important, pathogenically, than an increased peptic secretion. At present long-term prognosis of our patients is unknown.

Ulcera duodenale in due gemelli dizigoti / Sanna, Cm; Antonucci, Roberto; Corda, R.. - In: PEDIATRIA MEDICA E CHIRURGICA. - ISSN 0391-5387. - 12:1(1990), pp. 95-98.

Ulcera duodenale in due gemelli dizigoti

ANTONUCCI, Roberto;
1990

Abstract

We report two cases of duodenal ulcer (DU) identified at endoscopy in a pair of dizygotic twins; their outstanding clinically recognizable features were a very early onset, a great familiar occurrence, a lack of triggering conditions (drugs, burns, stress, sepsis, respiratory distress), normal serum levels of gastrin and pepsinogen I, inadequate response to medical treatment with H2-receptor antagonists, but satisfactory response to associated therapy with H2-receptor antagonists and sucralfate. Results of this study show that examined twins were affected by a form of early-onset primary DU, probably inherited like an autosomal dominant disorder with high degree of penetrance, associated with normal serum pepsinogen I and gastrin; in this form of Du a decreased tissue resistance of duodenal mucosa is likely more important, pathogenically, than an increased peptic secretion. At present long-term prognosis of our patients is unknown.
Ulcera duodenale in due gemelli dizigoti / Sanna, Cm; Antonucci, Roberto; Corda, R.. - In: PEDIATRIA MEDICA E CHIRURGICA. - ISSN 0391-5387. - 12:1(1990), pp. 95-98.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/82572
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