Eight new chiral oxazolinylpyridines were prepared and assessed in the enantioselective palladium-catalyzed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethyl malonate. Catalytic activity and enantioselectivity were found to be highly dependent upon the steric requirement of the substituent on the pyridine ring: enantioselectivity up to 92% has been obtained.
Steric effects of the ligand in the enantioselective palladium-catalyzed allylic alkylation using chiral oxazolinylpiridines / Chelucci, Giorgio Adolfo; Medici, S; A., Saba. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 10:(1999), pp. 543-550. [10.1016/S0957-4166(99)00023-3]
Steric effects of the ligand in the enantioselective palladium-catalyzed allylic alkylation using chiral oxazolinylpiridines
CHELUCCI, Giorgio Adolfo;
1999-01-01
Abstract
Eight new chiral oxazolinylpyridines were prepared and assessed in the enantioselective palladium-catalyzed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethyl malonate. Catalytic activity and enantioselectivity were found to be highly dependent upon the steric requirement of the substituent on the pyridine ring: enantioselectivity up to 92% has been obtained.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
