Based on experimental evidence suggesting a relationship between dopamine and mania, we proposed the antidepressant-induced dopaminergic supersensitivity as a model of antidepressant-related mania. We have previously shown the ability of carbamazepine, but not lithium, to prevent this phenomenon. Here we show that sodium valproate (50mg/kg/day for 3weeks) fails to prevent imipramine (20mg/kg/day for 3weeks)-induced sensitization to the locomotor response to the dopamine D2-like receptor agonist quinpirole (0.15mg/kg). Since lithium, carbamazepine and valproate are all considered poorly effective in the treatment of antidepressant-related mania, the validity of the proposed model should be disproved by the carbamazepine results, to which, however, a pharmacokinetic mechanism might have concurred.

Chronic valproate fails to prevent imipramine-induced behavioural sensitization to the dopamine D2-like receptor agonist quinpirole / D'Aquila, Paolo Stefano; Panin, F; Serra, Gino. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 535:(2006), pp. 208-211.

Chronic valproate fails to prevent imipramine-induced behavioural sensitization to the dopamine D2-like receptor agonist quinpirole

D'AQUILA, Paolo Stefano;SERRA, Gino
2006

Abstract

Based on experimental evidence suggesting a relationship between dopamine and mania, we proposed the antidepressant-induced dopaminergic supersensitivity as a model of antidepressant-related mania. We have previously shown the ability of carbamazepine, but not lithium, to prevent this phenomenon. Here we show that sodium valproate (50mg/kg/day for 3weeks) fails to prevent imipramine (20mg/kg/day for 3weeks)-induced sensitization to the locomotor response to the dopamine D2-like receptor agonist quinpirole (0.15mg/kg). Since lithium, carbamazepine and valproate are all considered poorly effective in the treatment of antidepressant-related mania, the validity of the proposed model should be disproved by the carbamazepine results, to which, however, a pharmacokinetic mechanism might have concurred.
Chronic valproate fails to prevent imipramine-induced behavioural sensitization to the dopamine D2-like receptor agonist quinpirole / D'Aquila, Paolo Stefano; Panin, F; Serra, Gino. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 535:(2006), pp. 208-211.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/81120
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