Quinoxaline derivatives have received much attention in recent years owing to their both biological properties and pharmaceutical applications. In this review we focus the attention on quinoxalin-2(3)-ones and quinoxalin-2,3-diones. These derivatives are particularly interesting since some of them showed antimicrobial (against several bacteria, viruses, fungi, etc), or anticancer activities. Furthermore, others are reported to be potent no-NMDA glutamate receptor antagonists, endowed with anxiolytic, deconditioning, analgesic, antispastic, antiallergic, antithrombotic activities. In this article we also report SAR studies and the most important methods of synthesis of the quinoxalin-2(3)-(di)ones.

Chemistry, biological properties and SAR analysis of quinoxalinones / Carta, Antonio; Piras, Sandra; Loriga, G; Paglietti, G.. - In: MINI-REVIEWS IN MEDICINAL CHEMISTRY. - ISSN 1389-5575. - 6:11(2006), pp. 1179-1220. [10.2174/138955706778742713]

Chemistry, biological properties and SAR analysis of quinoxalinones

CARTA, Antonio;PIRAS, Sandra;
2006

Abstract

Quinoxaline derivatives have received much attention in recent years owing to their both biological properties and pharmaceutical applications. In this review we focus the attention on quinoxalin-2(3)-ones and quinoxalin-2,3-diones. These derivatives are particularly interesting since some of them showed antimicrobial (against several bacteria, viruses, fungi, etc), or anticancer activities. Furthermore, others are reported to be potent no-NMDA glutamate receptor antagonists, endowed with anxiolytic, deconditioning, analgesic, antispastic, antiallergic, antithrombotic activities. In this article we also report SAR studies and the most important methods of synthesis of the quinoxalin-2(3)-(di)ones.
Chemistry, biological properties and SAR analysis of quinoxalinones / Carta, Antonio; Piras, Sandra; Loriga, G; Paglietti, G.. - In: MINI-REVIEWS IN MEDICINAL CHEMISTRY. - ISSN 1389-5575. - 6:11(2006), pp. 1179-1220. [10.2174/138955706778742713]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/79562
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 182
  • ???jsp.display-item.citation.isi??? 180
social impact