Spray-dried lactose is one of the most widely used filler-binders for direct compaction. The compactibility is a function of both primary particle size and the presence of amorphous lactose. Commercially available spray-dried lactose contains 15-20% amorphous lactose and 80-85% alpha-lactose monohydrate. A better understanding of the relationship between particle structure, physical properties and mechanisms of consolidation and compaction enabled an improved spray-dried lactose to be developed. The agglomerates of the improved product contain smaller primary a-lactose monohydrate particles than those of regular products. The present study shows that the improved spray-dried lactose has better compaction properties than regular spray-dried lactose.

Tabletting properties of an improved spray dried lactose / Rassu, Giovanna; EISSENS A., C; Bolhuis, G. K.. - In: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. - ISSN 1773-2247. - 16:6(2006), pp. 455-459.

Tabletting properties of an improved spray dried lactose

RASSU, Giovanna;
2006

Abstract

Spray-dried lactose is one of the most widely used filler-binders for direct compaction. The compactibility is a function of both primary particle size and the presence of amorphous lactose. Commercially available spray-dried lactose contains 15-20% amorphous lactose and 80-85% alpha-lactose monohydrate. A better understanding of the relationship between particle structure, physical properties and mechanisms of consolidation and compaction enabled an improved spray-dried lactose to be developed. The agglomerates of the improved product contain smaller primary a-lactose monohydrate particles than those of regular products. The present study shows that the improved spray-dried lactose has better compaction properties than regular spray-dried lactose.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/78321
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