This study compared the effectiveness of the QuantiFERON-TB Gold (QFT) assay with the Mantoux tuberculin skin test to detect Mycobacterium tuberculosis infection in 29 children during a school outbreak of tuberculosis. Of the 21 children with M. tuberculosis infection, 11 had a radiograph suggestive of the infection. The QFT assay was positive in all 21 of the children, and the Mantoux test was negative at first testing in 2 children (1 of whom was the sentinel case). The findings demonstrate that the QFT test is extremely useful in accurately identifying infected and uninfected children, permitting rapid intervention.
Performance of QuantiFERON-TB testing in a tuberculosis outbreak at a primary school / Molicotti, P; Bua, A; Mela, G; Olmeo, P; Delogu, R; Ortu, S; Sechi, La; Zanetti, S. - In: THE JOURNAL OF PEDIATRICS. - ISSN 0022-3476. - 152:4(2008), pp. 585-586. [10.1016/j.jpeds.2007.12.014]
Performance of QuantiFERON-TB testing in a tuberculosis outbreak at a primary school
MOLICOTTI P;SECHI LA;ZANETTI S
2008-01-01
Abstract
This study compared the effectiveness of the QuantiFERON-TB Gold (QFT) assay with the Mantoux tuberculin skin test to detect Mycobacterium tuberculosis infection in 29 children during a school outbreak of tuberculosis. Of the 21 children with M. tuberculosis infection, 11 had a radiograph suggestive of the infection. The QFT assay was positive in all 21 of the children, and the Mantoux test was negative at first testing in 2 children (1 of whom was the sentinel case). The findings demonstrate that the QFT test is extremely useful in accurately identifying infected and uninfected children, permitting rapid intervention.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
