Purpose: Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is one of the most common human genetic abnormalities, with a high prevalence in Sardinia, Italy, where the reported rates range from 10% to 15%. Hemizygous males have totally deficient erythrocytes. We are unaware of any previous report investigating intraocular pressure (IOP) in G6PD deficiency. The purpose of this study was to assess IOP in G6PD-deficient and G6PD-normal Sardinian men and ascertain whether there are significant differences between the two groups. Methods: IOP was measured by applanation tonometry in 104 G6PD-deficient and 104 age-matched G6PD-normal men. The Student t test was used to assess differences in IOP values between the two groups. Results: Mean IOP was 13.94 ± 2.62 mm Hg in G6PD-deficient men and 14.29 ± 2.84 mm Hg in G6PD-normal men, a not statistically significant result (P = 0.096). Conclusions: Results suggest that men with G6PD deficiency do not have a higher risk of increased IOP.

Intraocular pressure in Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency / Pinna, Antonio; Blasetti, F; Campesi, Ilaria; Scanu, B; Carru, C.. - In: ACTA OPHTHALMOLOGICA. - ISSN 1755-3768. - 93:Issue Supplement S255, October 2015(2015). [10.1111/j.1755-3768.2015.0364]

Intraocular pressure in Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency

PINNA, Antonio;CAMPESI, Ilaria;
2015

Abstract

Purpose: Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is one of the most common human genetic abnormalities, with a high prevalence in Sardinia, Italy, where the reported rates range from 10% to 15%. Hemizygous males have totally deficient erythrocytes. We are unaware of any previous report investigating intraocular pressure (IOP) in G6PD deficiency. The purpose of this study was to assess IOP in G6PD-deficient and G6PD-normal Sardinian men and ascertain whether there are significant differences between the two groups. Methods: IOP was measured by applanation tonometry in 104 G6PD-deficient and 104 age-matched G6PD-normal men. The Student t test was used to assess differences in IOP values between the two groups. Results: Mean IOP was 13.94 ± 2.62 mm Hg in G6PD-deficient men and 14.29 ± 2.84 mm Hg in G6PD-normal men, a not statistically significant result (P = 0.096). Conclusions: Results suggest that men with G6PD deficiency do not have a higher risk of increased IOP.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/68361
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