10–14 October 2010, Prague, Czech Republic Oral communication abstracts Sonographic findings before and after maternal administration of hyperimmune globulin in women with fetal cytomegalovirus infection N. Gussetti1, S. Visentin2, R. Manara3, MD Piga 4,V. Citton1, E. Salviato2, E. Cosmi2 1Infectious Disease, University of Padua, Padua, Italy; 2Obstetrics and Gynecology, University of Padua, Padua, Italy; 3Neuroradiology, University of Padua, Padua, Italy 4 Obstetrics and Gynecology, University of Sassari, Sassari, Italy Objectives: To assess ultrasound findings in pregnant women with fetal CMV infection treated with hyperimmune serum anti-‐CMV (CMV-‐Ig). Methods: Between January 2002 and December 2009, 501 women with primary CMV infection were identified. Among them, 47 women had a CMV-‐positive amniotic fluid (AF) sampled after 20 weeks of gestation and at least 6–8 weeks after primary infection. Twenty-‐three women received 200 UI/kg of CMV-‐Ig by single endovenous infusion between 23 and 29 weeks of gestation, 24 did not received CMV-‐Ig. Fetal ultrasonography was performed monthly. Follow up in infants was performed at a median age of 14 months (range 6–24). Results: In18/47 fetuses CMV-‐associated ultrasound abnormalities (IUGR, bowel/hepatic hyperechogenicity, cerebral periventricular with non-‐obese women. This information will be useful for genetic counseling prior to prenatal invasive procedures. OC20.04: Table 1. Maternal obesity and fetal loss rates from invasive procedures Obese: n (%) Non-‐obese: n (%) Adjusted OR (95% CI ) P-‐value CVS 50/780 (6.4) 257/3941 (6.5) 1.0 (0.7–1.3) 0.91 Amniocentesis 108/2265 (4.8) 301/7700 (3.9) 1.7 (1.2–2.1) <0.01 Ultrasound in Obstetrics & Gynecology 2010; 36 (Suppl. 1): 1–51 37
Sonographic findings before and after maternal administration of hyperimmune globulin in women with fetal cytomegalovirus infection / N., Gussetti1; S., Visentin2; R., Manara3; Piga, Maria Domenica; V., Citton1; E., Salviato2; E., Cosmi2. - In: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. - ISSN 0960-7692. - 36:37(2010), pp. 51-51.
Sonographic findings before and after maternal administration of hyperimmune globulin in women with fetal cytomegalovirus infection
PIGA, Maria Domenica;
2010-01-01
Abstract
10–14 October 2010, Prague, Czech Republic Oral communication abstracts Sonographic findings before and after maternal administration of hyperimmune globulin in women with fetal cytomegalovirus infection N. Gussetti1, S. Visentin2, R. Manara3, MD Piga 4,V. Citton1, E. Salviato2, E. Cosmi2 1Infectious Disease, University of Padua, Padua, Italy; 2Obstetrics and Gynecology, University of Padua, Padua, Italy; 3Neuroradiology, University of Padua, Padua, Italy 4 Obstetrics and Gynecology, University of Sassari, Sassari, Italy Objectives: To assess ultrasound findings in pregnant women with fetal CMV infection treated with hyperimmune serum anti-‐CMV (CMV-‐Ig). Methods: Between January 2002 and December 2009, 501 women with primary CMV infection were identified. Among them, 47 women had a CMV-‐positive amniotic fluid (AF) sampled after 20 weeks of gestation and at least 6–8 weeks after primary infection. Twenty-‐three women received 200 UI/kg of CMV-‐Ig by single endovenous infusion between 23 and 29 weeks of gestation, 24 did not received CMV-‐Ig. Fetal ultrasonography was performed monthly. Follow up in infants was performed at a median age of 14 months (range 6–24). Results: In18/47 fetuses CMV-‐associated ultrasound abnormalities (IUGR, bowel/hepatic hyperechogenicity, cerebral periventricular with non-‐obese women. This information will be useful for genetic counseling prior to prenatal invasive procedures. OC20.04: Table 1. Maternal obesity and fetal loss rates from invasive procedures Obese: n (%) Non-‐obese: n (%) Adjusted OR (95% CI ) P-‐value CVS 50/780 (6.4) 257/3941 (6.5) 1.0 (0.7–1.3) 0.91 Amniocentesis 108/2265 (4.8) 301/7700 (3.9) 1.7 (1.2–2.1) <0.01 Ultrasound in Obstetrics & Gynecology 2010; 36 (Suppl. 1): 1–51 37I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
