Efficient oxidation of primary alcohols to the corresponding carboxylic acids can be carried out at room temperature and in acetone/water, using trichloroisocyanuric acid (TCCA) in the presence of catalytic TEMPO. The mild conditions of this procedure and the total absence of any transition metal make this reaction suitable for safe laboratory use. A possible mechanism is presented and discussed.
Trichloroisocyanuric/TEMPO Oxidation of Alcohols under Mild Conditions: A Close Investigation / DE LUCA, Lidia Vera Giovanna; Giacomelli, Giampaolo; Masala, M.; Porcheddu, Andrea. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - 68:12(2003), pp. 4999-5001. [10.1021/jo034276b]
Trichloroisocyanuric/TEMPO Oxidation of Alcohols under Mild Conditions: A Close Investigation
DE LUCA, Lidia Vera Giovanna;GIACOMELLI, Giampaolo;PORCHEDDU, Andrea
2003-01-01
Abstract
Efficient oxidation of primary alcohols to the corresponding carboxylic acids can be carried out at room temperature and in acetone/water, using trichloroisocyanuric acid (TCCA) in the presence of catalytic TEMPO. The mild conditions of this procedure and the total absence of any transition metal make this reaction suitable for safe laboratory use. A possible mechanism is presented and discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
