The thalassaemias are blood disorders with hereditary transmission. Their distribution is global, with particular incidence in areas affected by malaria. Their diagnosis is mainly based on haematologic and genetic analyses. The aim of this study was to differentiate between persons with the thalassaemia trait and normal subjects by inspecting characteristics of haemochromocytometric data.The paper proposes an original method that is useful in screening activity for thalassaemia classification. A complete working system with a friendly graphical user interface is presented.A unique feature of the presented work is the adoption of a two-layered classification system based on Radial basis function, which improves the performance of the system.
A two-layered classifier based on the radial basis function for the screening of thalassaemia / Masala, Gl; Golosio, Bruno; Cutzu, R; Pola, R.. - In: COMPUTERS IN BIOLOGY AND MEDICINE. - ISSN 0010-4825. - 43:11(2013), p. 1724-1731. [10.1016/j.compbiomed.2013.08.020]
A two-layered classifier based on the radial basis function for the screening of thalassaemia
GOLOSIO, Bruno;
2013-01-01
Abstract
The thalassaemias are blood disorders with hereditary transmission. Their distribution is global, with particular incidence in areas affected by malaria. Their diagnosis is mainly based on haematologic and genetic analyses. The aim of this study was to differentiate between persons with the thalassaemia trait and normal subjects by inspecting characteristics of haemochromocytometric data.The paper proposes an original method that is useful in screening activity for thalassaemia classification. A complete working system with a friendly graphical user interface is presented.A unique feature of the presented work is the adoption of a two-layered classification system based on Radial basis function, which improves the performance of the system.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
