Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic: legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history(1). We used denaturing highperformance liquid chromatography (DHPLC; ref. 2) to identify 160 of the 166 bi-allelic and 1 tri-allelic site that formed a parsimonious; genealogy of 116 haplotypes, several of which display distinct population affinities based on the analysis of 1062 globally representative individuals. A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago.
Y chromosome sequence variation and the history of human populations / Underhill, Pa; Shen, Pd; Lin, Aa; Jin, L; Passarino, G; Yang, Wh; Kauffman, E; Bonne Tamir, B; Bertranpetit, J; Francalacci, Paolo; Ibrahim, M; Jenkins, T; Kidd, Jr; Mehdi, Sq; Seielstad, Mt; Wells, Rs; Piazza, A; Davis, Rw; Feldman, Mw; Cavalli Sforza, Ll; Oefner, Pj. - In: NATURE GENETICS. - ISSN 1061-4036. - 26:3(2000), pp. 358-361. [10.1038/81685]
Y chromosome sequence variation and the history of human populations
FRANCALACCI, Paolo;
2000-01-01
Abstract
Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic: legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history(1). We used denaturing highperformance liquid chromatography (DHPLC; ref. 2) to identify 160 of the 166 bi-allelic and 1 tri-allelic site that formed a parsimonious; genealogy of 116 haplotypes, several of which display distinct population affinities based on the analysis of 1062 globally representative individuals. A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
