Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic: legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history(1). We used denaturing highperformance liquid chromatography (DHPLC; ref. 2) to identify 160 of the 166 bi-allelic and 1 tri-allelic site that formed a parsimonious; genealogy of 116 haplotypes, several of which display distinct population affinities based on the analysis of 1062 globally representative individuals. A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago.

Y chromosome sequence variation and the history of human populations / Underhill, Pa; Shen, Pd; Lin, Aa; Jin, L; Passarino, G; Yang, Wh; Kauffman, E; Bonne Tamir, B; Bertranpetit, J; Francalacci, Paolo; Ibrahim, M; Jenkins, T; Kidd, Jr; Mehdi, Sq; Seielstad, Mt; Wells, Rs; Piazza, A; Davis, Rw; Feldman, Mw; Cavalli Sforza, Ll; Oefner, Pj. - In: NATURE GENETICS. - ISSN 1061-4036. - 26:3(2000), pp. 358-361. [10.1038/81685]

Y chromosome sequence variation and the history of human populations

FRANCALACCI, Paolo;
2000-01-01

Abstract

Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic: legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history(1). We used denaturing highperformance liquid chromatography (DHPLC; ref. 2) to identify 160 of the 166 bi-allelic and 1 tri-allelic site that formed a parsimonious; genealogy of 116 haplotypes, several of which display distinct population affinities based on the analysis of 1062 globally representative individuals. A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago.
2000
Y chromosome sequence variation and the history of human populations / Underhill, Pa; Shen, Pd; Lin, Aa; Jin, L; Passarino, G; Yang, Wh; Kauffman, E; Bonne Tamir, B; Bertranpetit, J; Francalacci, Paolo; Ibrahim, M; Jenkins, T; Kidd, Jr; Mehdi, Sq; Seielstad, Mt; Wells, Rs; Piazza, A; Davis, Rw; Feldman, Mw; Cavalli Sforza, Ll; Oefner, Pj. - In: NATURE GENETICS. - ISSN 1061-4036. - 26:3(2000), pp. 358-361. [10.1038/81685]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/62838
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