In this hospital-based, multicenter case-control study we investigated the prevalence of hepatitis B virus (HBV)-related markers and HBV/hepatitis C virus (HCV) co-infection among B-cell non-Hodgkin’s lymphoma (B-NHL) cases and controls. Four hundred newly diagnosed B-NHL cases and 392 controls from other departments of the same hospitals were studied. The prevalence of positivity for hepatitis B surface antigen (HBsAg) was 8.5% among B-NHL cases and 2.8% among controls (adjusted odds ratio, 3.67; 95% confidence interval, 1.75-7.66). HBV/HCV co-infection was found in four cases, but in no controls. The finding of a positive association between HBV infection and BNHL raises the possibility that HBV may play an etiologic role in the induction of B-NHL. Key words: HBV, B-NHL, prevalence, HBV-HCV co-infection.
High prevalence of hepatitis B virus infection in B-cell non-Hodgkin's lymphoma / Marcucci, F; Mele, A; Spada, E; Candido, A; Bianco, E; Pulsoni, A; Chionne, P; Madonna, E; Cotichini, R; Barbui, A; De Renzo, A; Dore, Fausto; Iannitto, E; Liso, V; Martino, B; Montanaro, M; Pagano, L; Musto, P; Rapicetta, M.. - In: HAEMATOLOGICA. - ISSN 0390-6078. - (2006).
High prevalence of hepatitis B virus infection in B-cell non-Hodgkin's lymphoma.
DORE, Fausto;
2006-01-01
Abstract
In this hospital-based, multicenter case-control study we investigated the prevalence of hepatitis B virus (HBV)-related markers and HBV/hepatitis C virus (HCV) co-infection among B-cell non-Hodgkin’s lymphoma (B-NHL) cases and controls. Four hundred newly diagnosed B-NHL cases and 392 controls from other departments of the same hospitals were studied. The prevalence of positivity for hepatitis B surface antigen (HBsAg) was 8.5% among B-NHL cases and 2.8% among controls (adjusted odds ratio, 3.67; 95% confidence interval, 1.75-7.66). HBV/HCV co-infection was found in four cases, but in no controls. The finding of a positive association between HBV infection and BNHL raises the possibility that HBV may play an etiologic role in the induction of B-NHL. Key words: HBV, B-NHL, prevalence, HBV-HCV co-infection.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
