BACKGROUND & AIMS: We sought to rest the diagnosric accuracy Of ultrasound (US), color Doppler US (CD-US), and contrast-enhanced US (CE-US) in the evaluation of inflammatory, activity in patients with Crohn's disease (CD), and to correlate the findings of these sonographic Studies with Inflammatory activity, as scored by the CD activity index (CDAI). METHODS: Patients with CD were enrolled in the Study. Radiologists performing the scans were blinded to clinical status. Baseline US, CD-US, and CE-US examinations were conducted with high-frequency probes (8-14 and 5-7 MHz) before and after injection Of Sulfur hexafluoride-filled microbubbles. The diagnostic accuracy of baseline US, CD-US, and CE-US were calculated by using the endoscopic and histologic findings as reference standards and correlated with the CDAIs by using the Pearson linear correlation coefficient. RESULTS: Forty-seven patients (20 men; 27 women mean age +/- SD, 38 +/- 14 years) with a CDAI > 150 (n = 30) or < 150 (n 17), were recruited. CE-US showed the highest performance, with 93.5% sensitivity, 93.7% specificity, and 93.6% overall accuracy. CE-US revealed 3 bowel wall perfusion patterns after microbubble injection: submucosal enhancement and inward mid outward transparietal enhancement. The linear correlation coefficient for CE-US versus CDAI was 0.74 (P < .0001); for baseline US (assessing thickness, length, and multilayer appearance of the diseased bowel) versus the CDAI, the coefficients were 0.68 (P < .0001), 0.47 (P = .0009), and 0.60 (P < .0001), respectively; and for CD-US versus CDAI the coefficient was 0.73 (P < .0001). CONCLUSIONS: CE-US has a high sensitivity and specificity m detecting inflammatory activity and a strong correlation with the CDAI. To view this article's video abstract, go to the AGA'S YouTube Channel.

Contrast Enhanced Ultrasonographic Evaluation of Inflammatory Activity in Crohn's Disease / Migaleddu, V; Scanu, Antonio Mario; Quaia, E; Azzali, L; COSSU ROCCA, Paolo Alessandro; Dore, Maria Pina; Scano, D; Virgilio, G.. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - 137:1(2009), pp. 43-52. [10.1053/j.gastro.2009.03.062]

Contrast Enhanced Ultrasonographic Evaluation of Inflammatory Activity in Crohn's Disease.

SCANU, Antonio Mario;COSSU ROCCA, Paolo Alessandro;DORE, Maria Pina;
2009-01-01

Abstract

BACKGROUND & AIMS: We sought to rest the diagnosric accuracy Of ultrasound (US), color Doppler US (CD-US), and contrast-enhanced US (CE-US) in the evaluation of inflammatory, activity in patients with Crohn's disease (CD), and to correlate the findings of these sonographic Studies with Inflammatory activity, as scored by the CD activity index (CDAI). METHODS: Patients with CD were enrolled in the Study. Radiologists performing the scans were blinded to clinical status. Baseline US, CD-US, and CE-US examinations were conducted with high-frequency probes (8-14 and 5-7 MHz) before and after injection Of Sulfur hexafluoride-filled microbubbles. The diagnostic accuracy of baseline US, CD-US, and CE-US were calculated by using the endoscopic and histologic findings as reference standards and correlated with the CDAIs by using the Pearson linear correlation coefficient. RESULTS: Forty-seven patients (20 men; 27 women mean age +/- SD, 38 +/- 14 years) with a CDAI > 150 (n = 30) or < 150 (n 17), were recruited. CE-US showed the highest performance, with 93.5% sensitivity, 93.7% specificity, and 93.6% overall accuracy. CE-US revealed 3 bowel wall perfusion patterns after microbubble injection: submucosal enhancement and inward mid outward transparietal enhancement. The linear correlation coefficient for CE-US versus CDAI was 0.74 (P < .0001); for baseline US (assessing thickness, length, and multilayer appearance of the diseased bowel) versus the CDAI, the coefficients were 0.68 (P < .0001), 0.47 (P = .0009), and 0.60 (P < .0001), respectively; and for CD-US versus CDAI the coefficient was 0.73 (P < .0001). CONCLUSIONS: CE-US has a high sensitivity and specificity m detecting inflammatory activity and a strong correlation with the CDAI. To view this article's video abstract, go to the AGA'S YouTube Channel.
2009
Contrast Enhanced Ultrasonographic Evaluation of Inflammatory Activity in Crohn's Disease / Migaleddu, V; Scanu, Antonio Mario; Quaia, E; Azzali, L; COSSU ROCCA, Paolo Alessandro; Dore, Maria Pina; Scano, D; Virgilio, G.. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - 137:1(2009), pp. 43-52. [10.1053/j.gastro.2009.03.062]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/62445
Citazioni
  • ???jsp.display-item.citation.pmc??? 45
  • Scopus 185
  • ???jsp.display-item.citation.isi??? 163
social impact