A new series of arylidene 5-phenyl-4-R-pyrrole-3-carbohydrazides 1a-j were prepared and evaluated for their analgesic-antiinflammatory activities. All synthesized compounds showed a significant analgesic action in mice after intraperitoneal administration at a dose of 100 μM/kg. Two of these, 1b, (4′-methylbenzylidene)-5-phenyl-1 H-pyrrole-3-carbohydrazide, and 1d, (4′-chlorobenzylidene)-5-phenyl-1H-pyrrole-3-carbohydrazide, were found to be more potent as antinociceptive agents respect to dipyrone and indometacin, used as reference drugs. Among compounds 1, only 1b showed a moderate antiinflammatory effect in rats while 1d proved to be a potent non antiinflammatory analgesic.

Synthesis and analgesic-antiinflammatory activities of novel acylarylhydrazones with a 5-phenyl-4-R-3-pyrrolyl-acyl moiety / Murineddu, Gabriele; G., Loriga; Gavini, Elisabetta; Peana, Alessandra Tiziana; Pinna, Gerard Aime. - In: ARCHIV DER PHARMAZIE. - ISSN 0365-6233. - 334:12(2001), pp. 373-398. [10.1002/1521-4184(200112)334:12<393::AID-ARDP393>3.0.CO;2-P]

Synthesis and analgesic-antiinflammatory activities of novel acylarylhydrazones with a 5-phenyl-4-R-3-pyrrolyl-acyl moiety

MURINEDDU, Gabriele;GAVINI, Elisabetta;PEANA, Alessandra Tiziana;PINNA, Gerard Aime
2001

Abstract

A new series of arylidene 5-phenyl-4-R-pyrrole-3-carbohydrazides 1a-j were prepared and evaluated for their analgesic-antiinflammatory activities. All synthesized compounds showed a significant analgesic action in mice after intraperitoneal administration at a dose of 100 μM/kg. Two of these, 1b, (4′-methylbenzylidene)-5-phenyl-1 H-pyrrole-3-carbohydrazide, and 1d, (4′-chlorobenzylidene)-5-phenyl-1H-pyrrole-3-carbohydrazide, were found to be more potent as antinociceptive agents respect to dipyrone and indometacin, used as reference drugs. Among compounds 1, only 1b showed a moderate antiinflammatory effect in rats while 1d proved to be a potent non antiinflammatory analgesic.
Synthesis and analgesic-antiinflammatory activities of novel acylarylhydrazones with a 5-phenyl-4-R-3-pyrrolyl-acyl moiety / Murineddu, Gabriele; G., Loriga; Gavini, Elisabetta; Peana, Alessandra Tiziana; Pinna, Gerard Aime. - In: ARCHIV DER PHARMAZIE. - ISSN 0365-6233. - 334:12(2001), pp. 373-398. [10.1002/1521-4184(200112)334:12<393::AID-ARDP393>3.0.CO;2-P]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/61988
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