Introduction: HIV infection is considered a risk factor for severe outcomes of influenza A(H1N1)v infection. However, data on immune response against influenza A(H1N1)v virus in HIV-infected patients are lacking.Methodology: Data from seven HIV-positive and 14 HIV-negative patients infected with A(H1N1)v and from 23 HIV-positive and six HIV-negative asymptomatic controls were analyzed to evaluate the clinical picture, A(H1N1)v viral shedding, and the immune response against the virus.Results: Patients displayed mainly upper respiratory tract diseases (57.1%), while pneumonia was diagnosed only in HIV-negative patients (23.8% of subjects, of which 4.8% required intensive care unit admission). At day seven, 29% of HIV-infected patients were still positive for A(H1N1)v by RT-PCR on nasopharyngeal swabs. Interestingly, a persistence of CXCL10 secretion at high level and lower IL-6 levels was observed in HIV-positive subjects. The geometric mean haemagglutination inhibition titer (HI-GMT) and anti-influenza IgM levels were lower in HIV-positive individuals while anti-influenza IgG levels remained similar in the two groups.Conclusions: The immune impairment due to HIV infection could affect A(H1N1)v clearance and could lead to a lower antibody response and a persistent secretion of CXCL10 at high levels. However, the lower IL-6 secretion and treatment with highly active antiretroviral therapy (HAART) could result in a milder clinical picture.

Immune response to influenza A(H1N1)v in HIV-infected patients / Sansonetti, P; Sali, M; Fabbiani, M; Morandi, M; Martucci, R; Danesh, A; Delogu, G; Bermejo Martin, J; Sanguinetti, M; Kelvin, D; Cauda, R; Fadda, G; Rubino, Salvatore. - In: JOURNAL OF INFECTION IN DEVELOPING COUNTRIES. - ISSN 2036-6590. - 8:1(2014), pp. 101-109. [10.3855/jidc.3147]

Immune response to influenza A(H1N1)v in HIV-infected patients

RUBINO, Salvatore
2014-01-01

Abstract

Introduction: HIV infection is considered a risk factor for severe outcomes of influenza A(H1N1)v infection. However, data on immune response against influenza A(H1N1)v virus in HIV-infected patients are lacking.Methodology: Data from seven HIV-positive and 14 HIV-negative patients infected with A(H1N1)v and from 23 HIV-positive and six HIV-negative asymptomatic controls were analyzed to evaluate the clinical picture, A(H1N1)v viral shedding, and the immune response against the virus.Results: Patients displayed mainly upper respiratory tract diseases (57.1%), while pneumonia was diagnosed only in HIV-negative patients (23.8% of subjects, of which 4.8% required intensive care unit admission). At day seven, 29% of HIV-infected patients were still positive for A(H1N1)v by RT-PCR on nasopharyngeal swabs. Interestingly, a persistence of CXCL10 secretion at high level and lower IL-6 levels was observed in HIV-positive subjects. The geometric mean haemagglutination inhibition titer (HI-GMT) and anti-influenza IgM levels were lower in HIV-positive individuals while anti-influenza IgG levels remained similar in the two groups.Conclusions: The immune impairment due to HIV infection could affect A(H1N1)v clearance and could lead to a lower antibody response and a persistent secretion of CXCL10 at high levels. However, the lower IL-6 secretion and treatment with highly active antiretroviral therapy (HAART) could result in a milder clinical picture.
2014
Immune response to influenza A(H1N1)v in HIV-infected patients / Sansonetti, P; Sali, M; Fabbiani, M; Morandi, M; Martucci, R; Danesh, A; Delogu, G; Bermejo Martin, J; Sanguinetti, M; Kelvin, D; Cauda, R; Fadda, G; Rubino, Salvatore. - In: JOURNAL OF INFECTION IN DEVELOPING COUNTRIES. - ISSN 2036-6590. - 8:1(2014), pp. 101-109. [10.3855/jidc.3147]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/61370
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