It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable.

Parameters for reliable results in genetic association studies in common disease / Dahlman, I; Eaves, Ia; Kosoy, R; Morrison, Va; Heward, J; Gough, Scl; Allahabadia, A; Franklyn, Ja; Tuomilehto, J; Tuomilehto Wolf, E; Cucca, Francesco; Guja, C; Ionescu Tirgoviste, C; Stevens, H; Carr, P; Nutland, S; Mckinney, P; Shield, Jp; Wang, W; Cordell, Hj; Walker, N; Todd, Ja; Concannon, P.. - In: NATURE GENETICS. - ISSN 1061-4036. - 30:2(2002), pp. 149-150. [10.1038/ng825]

Parameters for reliable results in genetic association studies in common disease

CUCCA, Francesco;
2002-01-01

Abstract

It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable.
2002
Parameters for reliable results in genetic association studies in common disease / Dahlman, I; Eaves, Ia; Kosoy, R; Morrison, Va; Heward, J; Gough, Scl; Allahabadia, A; Franklyn, Ja; Tuomilehto, J; Tuomilehto Wolf, E; Cucca, Francesco; Guja, C; Ionescu Tirgoviste, C; Stevens, H; Carr, P; Nutland, S; Mckinney, P; Shield, Jp; Wang, W; Cordell, Hj; Walker, N; Todd, Ja; Concannon, P.. - In: NATURE GENETICS. - ISSN 1061-4036. - 30:2(2002), pp. 149-150. [10.1038/ng825]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/60866
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 202
  • ???jsp.display-item.citation.isi??? 181
social impact