Novel type of VanB(2) teicoplanin-resistant hospital-associated Enterococcus faecium

Santona, Antonella; Paglietti, Bianca; Al Qahtani, Ahmed A.; Bohol, Marie Fe F.; Senok, Abiola; Deligios, Massimo; Rubino, Salvatore; Al Ahdal, Mohammed N.

doi:10.1016/j.ijantimicag.2014.05.005

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Seven high-risk clones of vancomycin-resistant Enterococcus faecium (VREF) belonging to clonal complex 17 were identified using multilocus sequence typing (MLST) among clinical isolates from Saudi Arabia. Among these isolates, a new hospital-associated sequence type (ST795), VanB(2)-type teicoplanin-resistant strain was detected. Its unusual phenotype resulted from a new combination of mutations in the ddl, vanS and vanW genes, which confirmed the trend of evolution in VanB-type resistance. Furthermore, characteristics of adaptation and persistence in the hospital environment of ST795 were emphasised by the presence of genes and clusters recognised to be specific for hospital-associated VREF. (C) 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

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Titolo:	Novel type of VanB(2) teicoplanin-resistant hospital-associated Enterococcus faecium
Autori:	Santona, Antonella Paglietti, Bianca Al Qahtani, Ahmed A. Bohol, Marie Fe F. Senok, Abiola Deligios, Massimo RUBINO, Salvatore Al Ahdal, Mohammed N. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2014
Rivista:	INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Abstract:	Seven high-risk clones of vancomycin-resistant Enterococcus faecium (VREF) belonging to clonal complex 17 were identified using multilocus sequence typing (MLST) among clinical isolates from Saudi Arabia. Among these isolates, a new hospital-associated sequence type (ST795), VanB(2)-type teicoplanin-resistant strain was detected. Its unusual phenotype resulted from a new combination of mutations in the ddl, vanS and vanW genes, which confirmed the trend of evolution in VanB-type resistance. Furthermore, characteristics of adaptation and persistence in the hospital environment of ST795 were emphasised by the presence of genes and clusters recognised to be specific for hospital-associated VREF. (C) 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Handle:	http://hdl.handle.net/11388/60115
Appare nelle tipologie:	1.1 Articolo in rivista

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