Seven high-risk clones of vancomycin-resistant Enterococcus faecium (VREF) belonging to clonal complex 17 were identified using multilocus sequence typing (MLST) among clinical isolates from Saudi Arabia. Among these isolates, a new hospital-associated sequence type (ST795), VanB(2)-type teicoplanin-resistant strain was detected. Its unusual phenotype resulted from a new combination of mutations in the ddl, vanS and vanW genes, which confirmed the trend of evolution in VanB-type resistance. Furthermore, characteristics of adaptation and persistence in the hospital environment of ST795 were emphasised by the presence of genes and clusters recognised to be specific for hospital-associated VREF. (C) 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Novel type of VanB(2) teicoplanin-resistant hospital-associated Enterococcus faecium / Santona, Antonella; Paglietti, Bianca; Al Qahtani, Ahmed A.; Bohol, Marie Fe F.; Senok, Abiola; Deligios, Massimo; Rubino, Salvatore; Al Ahdal, Mohammed N.. - In: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. - ISSN 0924-8579. - 44:2(2014), pp. 156-159. [10.1016/j.ijantimicag.2014.05.005]
Novel type of VanB(2) teicoplanin-resistant hospital-associated Enterococcus faecium
Paglietti, Bianca;RUBINO, Salvatore;
2014-01-01
Abstract
Seven high-risk clones of vancomycin-resistant Enterococcus faecium (VREF) belonging to clonal complex 17 were identified using multilocus sequence typing (MLST) among clinical isolates from Saudi Arabia. Among these isolates, a new hospital-associated sequence type (ST795), VanB(2)-type teicoplanin-resistant strain was detected. Its unusual phenotype resulted from a new combination of mutations in the ddl, vanS and vanW genes, which confirmed the trend of evolution in VanB-type resistance. Furthermore, characteristics of adaptation and persistence in the hospital environment of ST795 were emphasised by the presence of genes and clusters recognised to be specific for hospital-associated VREF. (C) 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
