A new series of 4-carbamoyl-6-β-thienyl-4,5-dihydropyridazin-3-(2H)ones 4a-g have been synthesized and tested for their anti-inflammatory and analgesic properties. Among the tested compounds, only 4f at 1 mmole/Kg showed antiinflammatory activity that was comparable with that of indomethacin (5 mg/Kg) though of shorter duration. Compounds 4a, 4e and especially 4g at 0.2 mmoles/Kg displayed relevant analgesic activity, 4g being the most potent derivative in the writhing test. Compounds 4c and 4g were found to possess analgesic activity also in the hot plate test.
Synthesis and pharmacological activity of 4-carbamoyl-6-b-thienyl-4,5-dihydropyridazin-3-(2H) ones / Pinna, Gerard Aime; Curzu, Mm; Gavini, Elisabetta; Mulè, A; Pirisino, G; Satta, M; Peana, Alessandra Tiziana. - In: IL FARMACO. - ISSN 0014-827X. - 48:9(1993), pp. 1239-1247.
Synthesis and pharmacological activity of 4-carbamoyl-6-b-thienyl-4,5-dihydropyridazin-3-(2H) ones
PINNA, Gerard Aime;GAVINI, Elisabetta;PEANA, Alessandra Tiziana
1993-01-01
Abstract
A new series of 4-carbamoyl-6-β-thienyl-4,5-dihydropyridazin-3-(2H)ones 4a-g have been synthesized and tested for their anti-inflammatory and analgesic properties. Among the tested compounds, only 4f at 1 mmole/Kg showed antiinflammatory activity that was comparable with that of indomethacin (5 mg/Kg) though of shorter duration. Compounds 4a, 4e and especially 4g at 0.2 mmoles/Kg displayed relevant analgesic activity, 4g being the most potent derivative in the writhing test. Compounds 4c and 4g were found to possess analgesic activity also in the hot plate test.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
