The preparation of ketoprofen spray-dried microspheres can be affected by the long drug recrystallization time. Polymer type and drug-polymer ratio as well as manufacturing parameters affect the preparation. The purpose of this work was to evaluate the possibility to obtain ketoprofen spray-dried microspheres using the Eudragit® RS and RL; the influence of the spray-drying parameters on morphology, dimension, and physical stability of microspheres was studied. Ketoprofen microspheres based on Eudragit® blend can be prepared by spray-drying and the nebulization parameters do not influence significantly particle properties; nevertheless, they can be affected by drying and storage methods. No effect of the container material is found.
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|Titolo:||Ketoprofen spray-dried microspheres based on Eudragit® RS and RL: study of the manufacturing parameters|
|Autori interni:||GAVINI, Elisabetta|
|Data di pubblicazione:||2008|
|Rivista:||DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY|
|Appare nelle tipologie:||1.1 Articolo in rivista|