p53 codon 72 genotypes in Nuoro and Oristano areas: *Arg/*Arg genotype is much more frequent in Oristano than in Nuoro (p=0.024). The frequency of *Arg allele is 82.6% in Oristano and 69.1% in Nuoro (p=0.04). In accordance with experimental studies suggesting apoptosis of the liver cells as a defense mechanism against parasite invasion, *Arg allele favoring apoptosis seems to have been selected positively in area of Sardinia exposed in the past to heavy malaria endemia.
P 53 Codon 72 and Past Malaria Morbidity in Sardinia / Gloria Bottini, F; Meloni, Gianfranco; Saccucci, P; Bottini, E.. - In: MALARIA CHEMOTHERAPY, CONTROL & ELIMINATION. - ISSN 2090-2778. - 2:1(2013), pp. 107-107. [10.4172/2090-2778.1000107]
P 53 Codon 72 and Past Malaria Morbidity in Sardinia
MELONI, Gianfranco;
2013-01-01
Abstract
p53 codon 72 genotypes in Nuoro and Oristano areas: *Arg/*Arg genotype is much more frequent in Oristano than in Nuoro (p=0.024). The frequency of *Arg allele is 82.6% in Oristano and 69.1% in Nuoro (p=0.04). In accordance with experimental studies suggesting apoptosis of the liver cells as a defense mechanism against parasite invasion, *Arg allele favoring apoptosis seems to have been selected positively in area of Sardinia exposed in the past to heavy malaria endemia.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
