A series of substituted N-cycloalkyl benzamides, cinnamamides, and indole-3-carboxamides were synthesized and evaluated for their analgesic, antiinflammatory activities as well as for their gastrointestinal irritation liability. Indomethacin was used as reference drug in both tests: Compounds 1k, 1b, 1h, 1j, and 1g were the most active in the antiinflammatory paw edema inhibition test, with a sharply dose-dependent effect. In terms of the analgesic activity (acetic acid writhing test), the most active compound was 5a followed by 3a, but many other compounds were found to have a non- negligible potency. Even in this case, the effect was dose dependent.
Anti-inflammatory and Analgesic Amides: New Developments / Palomba, Michele Francesco Luigi; Pau, Amedeo; Boatto, Gianpiero; Asproni, Battistina; Auzzas, L; Cerri, R; Arenare, L; Filippelli, W; Falcone, G; Motola, G.. - In: ARCHIV DER PHARMAZIE. - ISSN 0365-6233. - 333:1(2000), pp. 17-26. [10.1002/(SICI)1521-4184(200001)333:1<17::AID-ARDP17>3.0.CO;2-0]
Anti-inflammatory and Analgesic Amides: New Developments
PALOMBA, Michele Francesco Luigi;PAU, Amedeo;BOATTO, Gianpiero;ASPRONI, Battistina;
2000-01-01
Abstract
A series of substituted N-cycloalkyl benzamides, cinnamamides, and indole-3-carboxamides were synthesized and evaluated for their analgesic, antiinflammatory activities as well as for their gastrointestinal irritation liability. Indomethacin was used as reference drug in both tests: Compounds 1k, 1b, 1h, 1j, and 1g were the most active in the antiinflammatory paw edema inhibition test, with a sharply dose-dependent effect. In terms of the analgesic activity (acetic acid writhing test), the most active compound was 5a followed by 3a, but many other compounds were found to have a non- negligible potency. Even in this case, the effect was dose dependent.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
