Partial structures of prazosin have been synthesised and tested for inhibition of Transport-P in order to identify the structural features of prazosin, which appear to be involved in binding to the putative transporter. It is shown that the pyrimidinyl 4- amino group is critically important for binding but that the 6,7-dimethoxy and 2-furoyl groups are not essential.
Search for the pharmacophore in prazosin for Transport-P / PATRICIA A., Zunszain; Cesare, Federico; Sechi, Mario; SAAD AL, Damluji; C., ROBIN GANELLIN. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 13:(2005), pp. 3681-3689.
Search for the pharmacophore in prazosin for Transport-P
SECHI, Mario;
2005-01-01
Abstract
Partial structures of prazosin have been synthesised and tested for inhibition of Transport-P in order to identify the structural features of prazosin, which appear to be involved in binding to the putative transporter. It is shown that the pyrimidinyl 4- amino group is critically important for binding but that the 6,7-dimethoxy and 2-furoyl groups are not essential.File in questo prodotto:
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