Some new imidazolinyl-pyrazoles (4) were synthesized by condensation of 2-imidazolylhydrazine hydroiodid (1a) with β-ketoesters to afford the intermediate 3 that, as free base, ring closes only to 4. The attempt to obtain the imidazo-triazepinone 5, starting from 2-imidazolinyl-2-methylhydrazine, was accomplished, in low yield, only in reacting with ethyl acetoacetate. The pharmacological evaluation of antiinflammatory and analgesic activities of pyrazoles 4a-f revealed an appreciable antiinflammatory activity.
Synthesis and antiinflammatory activity of some imidazolinyl - pyrazole derivatives / F., Savelli; A., Boido; M., Satta; Peana, Alessandra Tiziana. - In: IL FARMACO. - ISSN 0014-827X. - 51:2(1996), pp. 141-143.
Synthesis and antiinflammatory activity of some imidazolinyl - pyrazole derivatives
PEANA, Alessandra Tiziana
1996-01-01
Abstract
Some new imidazolinyl-pyrazoles (4) were synthesized by condensation of 2-imidazolylhydrazine hydroiodid (1a) with β-ketoesters to afford the intermediate 3 that, as free base, ring closes only to 4. The attempt to obtain the imidazo-triazepinone 5, starting from 2-imidazolinyl-2-methylhydrazine, was accomplished, in low yield, only in reacting with ethyl acetoacetate. The pharmacological evaluation of antiinflammatory and analgesic activities of pyrazoles 4a-f revealed an appreciable antiinflammatory activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
