A series of twelve novel pyrido[2,3-g]quinoxalinones (3-14), variously substituted at the C-3 position, was synthesized, structurally determined and submitted to a preliminary in vitro evaluation for antibacterial, anticandida and anticancer activities. Results of the antimicrobial screening showed that all compounds, with the exception of 6, 11 and 12, exhibited interesting activity against all strains tested; while compound 10 was found to have encouraging in vitro anticancer activity at a concentration of 10(-4) M. (C) 2001 Elsevier Science S.A. All rights reserved.
Novel functionalized pyrido[2,3-g]quinoxalinones as antibacterial, antifungal and anticancer agents / Carta, Antonio; Sanna, P; Gherardini, L; Usai, D; Zanetti, Stefania Anna Lucia. - In: IL FARMACO. - ISSN 0014-827X. - 56:(2001), pp. 933-938. [10.1016/S0014-827X(01)01161-2]
Novel functionalized pyrido[2,3-g]quinoxalinones as antibacterial, antifungal and anticancer agents
CARTA, Antonio;ZANETTI, Stefania Anna Lucia
2001-01-01
Abstract
A series of twelve novel pyrido[2,3-g]quinoxalinones (3-14), variously substituted at the C-3 position, was synthesized, structurally determined and submitted to a preliminary in vitro evaluation for antibacterial, anticandida and anticancer activities. Results of the antimicrobial screening showed that all compounds, with the exception of 6, 11 and 12, exhibited interesting activity against all strains tested; while compound 10 was found to have encouraging in vitro anticancer activity at a concentration of 10(-4) M. (C) 2001 Elsevier Science S.A. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
