A protocol for the synthesis of quinolines substituted on both pyridine and benzo-fused rings is reported. The method is based on the formylation of a substituted N-(tert-butoxycarbonyl)aniline followed by direct cyclisation and aromatisation of the intermediate product obtained by condensation of the formed N-Boc o-aminobenzaldehyde with an enolisable carbonyl compound. Yields upto 88% have been obtained.
Synthesis of regiospecifically substituted quinolines from anilines / Chelucci, Giorgio Adolfo; Manca, A.; Pinna, Gerard Aime. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 46:5(2005), pp. 767-770. [10.1016/j.tetlet.2004.12.020]
Synthesis of regiospecifically substituted quinolines from anilines
CHELUCCI, Giorgio Adolfo;PINNA, Gerard Aime
2005-01-01
Abstract
A protocol for the synthesis of quinolines substituted on both pyridine and benzo-fused rings is reported. The method is based on the formylation of a substituted N-(tert-butoxycarbonyl)aniline followed by direct cyclisation and aromatisation of the intermediate product obtained by condensation of the formed N-Boc o-aminobenzaldehyde with an enolisable carbonyl compound. Yields upto 88% have been obtained.File in questo prodotto:
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