In recent studies performed in our laboratory we have shown that acute administration of ()-linalool, the natural occurring enantiomer in essential oils, possesses anti-inflammatory, antihyperalgesic and antinociceptive effects in different animal models. The antihyperalgesic and antinociceptive effects of ()-linalool have been ascribed to its capacity in stimulating the opioidergic, cholinergic and dopaminergic systems, as well as to its interaction with K+ channels, or to its local anaesthetic activity and/or to the negative modulation of glutamate transmission. Activation of A1 or A2A receptors has been shown to induce antinociceptive effects, and the possible involvement of adenosine in ()-linalool antinociceptive effect, has not been elucidated yet. Therefore, in the present study, we have investigated the effects of 1,3-dipropyl-8- cyclopentylxanthine (DPCPX), a selective adenosine A1 receptor antagonist and the effects of 3,7-dimethyl-1-propargilxanthine (DMPX), a selective adenosine A2A receptor antagonist on the antinociception of ()-linalool in mice, measured in the hot-plate test. Both DPCPX (0.1 mg/ kg; i.p.) and DMPX (0.1 mg/kg; i.p.) pre-treatment significantly depressed the antinociceptive effect of ()-linalool at the highest doses tested. These findings demonstrated that the effect of ()-linalool on pain responses is, at least partially, mediated by the activity of adenosine A1 and A2A receptors.

Involvement of adenosine A1 and A2A receptors in (―)-linalool-induced antinociception / Peana, Alessandra Tiziana; P., Rubattu; G. G., Piga; S., Fumagalli; Boatto, Gianpiero; Pippia, Proto Gavino; M. G., DE MONTIS. - In: LIFE SCIENCES. - ISSN 0024-3205. - 78:21(2006), pp. 2471-2474. [10.1016/j.lfs.2005.10.025]

Involvement of adenosine A1 and A2A receptors in (―)-linalool-induced antinociception

PEANA, Alessandra Tiziana;BOATTO, Gianpiero;PIPPIA, Proto Gavino;
2006-01-01

Abstract

In recent studies performed in our laboratory we have shown that acute administration of ()-linalool, the natural occurring enantiomer in essential oils, possesses anti-inflammatory, antihyperalgesic and antinociceptive effects in different animal models. The antihyperalgesic and antinociceptive effects of ()-linalool have been ascribed to its capacity in stimulating the opioidergic, cholinergic and dopaminergic systems, as well as to its interaction with K+ channels, or to its local anaesthetic activity and/or to the negative modulation of glutamate transmission. Activation of A1 or A2A receptors has been shown to induce antinociceptive effects, and the possible involvement of adenosine in ()-linalool antinociceptive effect, has not been elucidated yet. Therefore, in the present study, we have investigated the effects of 1,3-dipropyl-8- cyclopentylxanthine (DPCPX), a selective adenosine A1 receptor antagonist and the effects of 3,7-dimethyl-1-propargilxanthine (DMPX), a selective adenosine A2A receptor antagonist on the antinociception of ()-linalool in mice, measured in the hot-plate test. Both DPCPX (0.1 mg/ kg; i.p.) and DMPX (0.1 mg/kg; i.p.) pre-treatment significantly depressed the antinociceptive effect of ()-linalool at the highest doses tested. These findings demonstrated that the effect of ()-linalool on pain responses is, at least partially, mediated by the activity of adenosine A1 and A2A receptors.
2006
Involvement of adenosine A1 and A2A receptors in (―)-linalool-induced antinociception / Peana, Alessandra Tiziana; P., Rubattu; G. G., Piga; S., Fumagalli; Boatto, Gianpiero; Pippia, Proto Gavino; M. G., DE MONTIS. - In: LIFE SCIENCES. - ISSN 0024-3205. - 78:21(2006), pp. 2471-2474. [10.1016/j.lfs.2005.10.025]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/57494
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