The effects of a few cytotoxic organogold(III) compounds on ovarian A2780 human cancer cells were investigated in comparison to cisplatin and oxaliplatin. The tested compounds produced significant antiproliferative effects and promoted apoptosis to a greater extent than platinum drugs while causing only modest cell cycle modifications. The mechanistic implications of these findings are discussed: mitochondrial pathways are proposed to be directly involved in the apoptotic process in relation to selective inhibition of thioredoxin reductase.
Mechanisms of cytotoxycity of selected organogold(III) compounds / Coronnello, M; Mini, E; Caciagli, B; Cinellu, Maria Agostina; Bindoli, A; Gabbiani, C; Messori, L.. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 48:(2005), pp. 6761-6765. [10.1021/jm050493o]
Mechanisms of cytotoxycity of selected organogold(III) compounds
CINELLU, Maria Agostina;
2005-01-01
Abstract
The effects of a few cytotoxic organogold(III) compounds on ovarian A2780 human cancer cells were investigated in comparison to cisplatin and oxaliplatin. The tested compounds produced significant antiproliferative effects and promoted apoptosis to a greater extent than platinum drugs while causing only modest cell cycle modifications. The mechanistic implications of these findings are discussed: mitochondrial pathways are proposed to be directly involved in the apoptotic process in relation to selective inhibition of thioredoxin reductase.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
