Since Chevens’ report, in the early 50’s that his patients under treatment with the aldehyde 067 dehydrogenase inhibitor, antabuse, could experience beneficial effects when drinking 068 small volumes of alcoholic beverages, the role of acetaldehyde (ACD) in the effects of 069 ethanol has been thoroughly investigated on pre-clinical grounds. Thus, after more than 070 25 years of intense research, a large number of studies have been published on the 071 motivational properties of ACD itself as well as on the role that ethanol-derived ACD 072 plays in the effects of ethanol. Accordingly, in particular with respect to the motivational 073 properties of ethanol, these studies were developed following two main strategies: on 074 one hand, were aimed to challenge the suggestion that also ACD may exert motivational 075 properties on its own, while, on the other, with the aid of enzymatic manipulations or 076 077 have a role in ethanol motivational effects. Furthermore, recent evidence significantly 078 ACD inactivation, were aimed to test the hypothesis that ethanol-derived ACD might contributed to highlight, as possible mechanisms of action of ACD, its ability to commit 079 080 either dopaminergic and opioidergic transmission as well as to activate the Extracellular signal Regulated Kinase cascade transduction pathway in reward-related brain structures. In conclusion, and despite the observation that ACD seems also to have inherited the elusive nature of its parent compound, the behavioral and biochemical evidence reviewed points to ACD as a neuroactive molecule able, on its own and as ethanol metabolite, to exert motivational effects.
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|Titolo:||Behavioral and biochemical evidence of the role of acetaldehyde in the motivational effects of ethanol|
|Data di pubblicazione:||2013|
|Appare nelle tipologie:||1.1 Articolo in rivista|