The reference ranges for blood Cu, Mn, Se and Zn of 215 adult subjects non-occupationally exposed and living in the Nuoro province (Sardinia, insular Italy) were assessed. Metals were determined by sector field inductively coupled plasma mass spectrometry after microwave-assisted acid digestion of blood. The blood reference ranges estimated as P5-P95 percentiles (geometric mean, GM) were 776-1495 mu g/L (1036 mu g/L) for Cu; 4.73-17.0 mu g/L (8.91 mu g/L) for Mn; 106-185 mu g/L (140 mu g/L) for Se and 4686-8585 mu g/L (6418 mu g/L) for Zn. These results were then stratified for sex, age, alcohol consumption, smoking habit and living area. The GM value of Cu was significantly higher in females (1127 mu g/L) than in males (957 mu g/L). Age, alcohol intake, smoking habit and residential area did not influence blood Cu. The GM of Mn was significantly higher in females (9.98 mu g/L) respect to males (8.01 mu g/L) and in drinkers (9.67 mu g/L) compared to non-drinkers (8.38 mu g/L). The other variables did not change the Mn data. Selenium concentrations did not differ significantly as a function of individuals factors. With reference to Zn, males had GM of 6804 mu g/L and females of 6031 mu g/L, and more blood Zn was found in subjects consuming alcohol (6618 mu g/L) respect to abstainers (6155 mu g/L). In addition, blood Zn was not affected by age, smoking habit and place of living. (C) 2010 Elsevier GmbH. All rights reserved.

Assessment of reference ranges of blood Cu,Mn,Se and Zn in a selected Italian population / Bocca, B.; Madeddu, Roberto Beniamino; Asara, Y.; Tolu, P.; Marchal, J. A.; Forte, G.. - In: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY. - ISSN 0946-672X. - 25:1(2011), pp. 19-26.

Assessment of reference ranges of blood Cu,Mn,Se and Zn in a selected Italian population

MADEDDU, Roberto Beniamino;
2011-01-01

Abstract

The reference ranges for blood Cu, Mn, Se and Zn of 215 adult subjects non-occupationally exposed and living in the Nuoro province (Sardinia, insular Italy) were assessed. Metals were determined by sector field inductively coupled plasma mass spectrometry after microwave-assisted acid digestion of blood. The blood reference ranges estimated as P5-P95 percentiles (geometric mean, GM) were 776-1495 mu g/L (1036 mu g/L) for Cu; 4.73-17.0 mu g/L (8.91 mu g/L) for Mn; 106-185 mu g/L (140 mu g/L) for Se and 4686-8585 mu g/L (6418 mu g/L) for Zn. These results were then stratified for sex, age, alcohol consumption, smoking habit and living area. The GM value of Cu was significantly higher in females (1127 mu g/L) than in males (957 mu g/L). Age, alcohol intake, smoking habit and residential area did not influence blood Cu. The GM of Mn was significantly higher in females (9.98 mu g/L) respect to males (8.01 mu g/L) and in drinkers (9.67 mu g/L) compared to non-drinkers (8.38 mu g/L). The other variables did not change the Mn data. Selenium concentrations did not differ significantly as a function of individuals factors. With reference to Zn, males had GM of 6804 mu g/L and females of 6031 mu g/L, and more blood Zn was found in subjects consuming alcohol (6618 mu g/L) respect to abstainers (6155 mu g/L). In addition, blood Zn was not affected by age, smoking habit and place of living. (C) 2010 Elsevier GmbH. All rights reserved.
2011
Assessment of reference ranges of blood Cu,Mn,Se and Zn in a selected Italian population / Bocca, B.; Madeddu, Roberto Beniamino; Asara, Y.; Tolu, P.; Marchal, J. A.; Forte, G.. - In: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY. - ISSN 0946-672X. - 25:1(2011), pp. 19-26.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/49097
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 92
  • ???jsp.display-item.citation.isi??? 86
social impact